黄皮酰胺的抑制脂质过氧化和脑保护作用  

ANTI-LIPIDPEROXIDATION AND CEREBRAL PROTECTIVE EFFECTS OF CLAUSENAMIDE

作　　者：刘云[1] 石成璋 张均田[1] 

机构地区：[1]中国医学科学院药物研究所,北京100050

出　　处：《药学学报》1991年第3期166-170,共5页Acta Pharmaceutica Sinica

摘　　要：黄皮酰胺是类似脑复康结构的一种化合物。实验表明po能明显延长小鼠断头后的张口呼吸时间和sc亚硝酸钠225 mg/kg后的动物存活时间。po黄皮酰胺100 mg/kg·bid×3能抑制由p0 50%乙醇(15 ml/kg)诱发小鼠肝脂质过氧化反应,使TBA反应值下降,明显激活肝和脑组织胞浆液中谷胱甘肽过氧化酶的活力。大鼠脑基底动脉条收缩实验结果表明,黄皮酰胺10^(-5)mol/L可明显抑制由5-HT,PGF_(2x)和花生四烯酸引起的血管收缩,提示黄皮酰胺有缓解血管痉挛,增加脑血流量的作用。Clausenamide is a compound isolated from Clausena lansium (lour) with the structure similar to piracetam. Pharmacological experiments showed that clausenamide po 100～200mg/kg prolonged both the duration of gasping after decapitation and the survival time after sc NaNO_2 225mg/kg, clausenamide at the concentration of 10^(-5) mol/L inhibited the contraction of basilar artery caused by 5--HT, PGF_(2α) and arachidonic acid, indicating that clausenamide is a cerebral protective agent. In addition, multiple doses clausenamide were shown to inhibit the liver lipid peroxidation. caused by 50% alcohol and increase the GSH-peroxidase activity significantly in rat liver and brain cytosol.

关 键 词：黄皮酰胺 脂质氧化 脑保护作用 

分 类 号：R965[医药卫生—药理学]