2,4-二氨基-5-甲基-6-(N-甲基取代苄氨基)喹唑啉的合成及其抗肿瘤和抗菌作用  

SYNTHESIS AND ANTIBACTERIAL AS WELL AS ANTINEO-PLASTIC ACTIVITIES OF 2,4-DIAMINO-5-METHYL-6-(N -METHYL-SUBSTITUTED BENZYL)AMINOQUINA-ZOLINES

作　　者：蒙小英[1] 张秀平[1] 陈秀华[1] 余爱珍[1] 

机构地区：[1]上海医药工业研究院,上海200433

出　　处：《药学学报》1991年第5期383-386,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金 No 2860202

摘　　要：作者曾报道2,4-二氨基-5-甲基-6-取代苄氨基喹唑啉衍生物有较好的抗疟和抗肿瘤作用。鉴于在2,4-二氨基-6-取代苄氨基喹唑啉的6位侧链氨基上引入甲基,可使抗肿瘤活性明显增强,因此设计合成了一系列2。This paper reports four methods for the synthesis of 2,4- diamino- 5 - methyl - 6 - ( N- methyl - substitutedbenzyl) aminoquinazolines. Six compounds were synthesized and all these compounds showed good anticancer and antibacterial activities. Among them, I_5 showed the strongest inhibition against L1210 Leukemia cell and further research has to be done.

关 键 词：喹唑啉类 化合物 合成 抗肿瘤作用 

分 类 号：R914.5[医药卫生—药物化学]