碳环核苷类化合物的合成  

SYNTHESIS OF ANALOGUES OF CARBOCYCLIC NUCLEOSIDE

作　　者：乔雷[1] 马灵台[1] 闵吉梅[1] 张礼和[1] 

机构地区：[1]北京医科大学药学院,北京100083

出　　处：《药学学报》1991年第6期420-425,共6页Acta Pharmaceutica Sinica

摘　　要：通过氯代环戊烯和相应的嘧啶碱基缩合,再环氧化和开环得到了5′-去羟甲基碳环核苷类似物。所合成化合物经体外L_(1210)和肝癌细胞筛选,并用2215细胞株进行抗乙肝病毒筛选,均未发现有意义的活性。The derivatives of 5'-dehydroxymethyl carbocyclic nucleoside were synthesized by condensation of cyclopentenyl chloride and corresponding pyrimidines followed by epoxidation and substitution. All compounds were screened for anticancer and antiviral activities and no activity was found.

关 键 词：碳环核苷 抗癌药 抗病毒药 

分 类 号：R962[医药卫生—药理学]