5-Fu区域化疗对大肠癌手术后肝转移影响的临床研究  

Clinical study on the impact of regional infusion of 5-Fu on the metastasis of colotectal cancer to the liver of patients after operation.

作　　者：周卫平[1] 刘海[1] 蔡国豪[1] 王国雄[1] 杨作衡[1] 汤鹏[1] 

机构地区：[1]海南省人民医院肿瘤外科,海口市570311

出　　处：《中国热带医学》2002年第2期183-184,共2页China Tropical Medicine

摘　　要：目的　探讨 5 -FU区域化疗是否可以减少大肠癌手术后肝转移的发生率。方法　 1994年 4月至 1998年 7月我们将符合研究标准的 117例患者进行了研究 ,手术中按随机分组 ,治疗组 5 7例 ,对照组 6 0例。治疗组 5 -FU5 0 0mg m2 ,连续 7d ,对照组不插管。所有患者至少随访 4年。结果　门静脉插管化疗的不良反应与全身化疗一样 ,主要是消化道症状和造血功能抑制 ,但都较轻微 ,可以耐受。对照组肝转移 13( 13 6 0 )例 ,治疗组肝转移 3( 3 5 7)例 (X2 =5 .1,P <0 .0 5 )。结论　大肠癌手术后门静脉插管化疗可减少肝转移的发生率 ,其不良反应是可以忍受的 ,它是值得广泛推广的治疗手段。Objective To value the effect of the regional infusion of 5-Fu on liver metastases from colorectal cancer.Methods From April, 1994 to July,1998, 117 cases of patient qualified with our standards were studied. They were randomized into two groups: therapy group, for which a catheter was placed through a mesenteric vein to the portal system, and 5-Fu at a dose of 500mg/m 2 was given by continuous intravenous infusion for 7 days. No catheter was placed in the control group. All patients were reevaluated for a minimum of 4 years. Results The main toxic reactions related to digestive system and blood-producing system, whereas they were almost invariably mild and transient. Objective liver metastases developed in 13/60 patients in the control group, in three of 57 patients in the 5-Fu group(X 2=5.1, P<0.05).Conclusion Adjuvant 5-Fu liver perfusions have a preventive role for liver metastasis from colorectal cancer with tolerable toxic reactions, so it is recommendable.

关 键 词：5-FU 大肠癌 肝转移 区域化疗 临床分析 

分 类 号：R735.34[医药卫生—肿瘤]