青花椒化学成分的研究  

STUDIES ON THE CHEMICAL CONSTITUENTS FROM THE PEEL OF ZANTHOXYLUM SCHINIFOLIUM SIEB ET ZUCC

作　　者：刘锁兰[1] 魏璐雪[1] 王动[2] 高从元[2] 

机构地区：[1]北京中医学院中药系植化室 [2]北京医科大学波谱分析室,北京100083

出　　处：《药学学报》1991年第11期836-840,共5页Acta Pharmaceutica Sinica

摘　　要：自青花椒(Zanthoxylum schinifolium Sieb et Zucc)的果皮中分离出五个化合物。经鉴定化合物Ⅰ为香柑内酯(bergamten),Ⅱ为伞形花内酯(umbelliferone)Ⅲ为茵芋碱(skimmianine),Ⅳ为N-甲基-2-庚基-4-啉酮(N-methyl-2-heptyl-4-quinolone)。Ⅱ,Ⅲ,Ⅳ均为首次从本植物中分出,Ⅳ是从植物中得到的新化合物,命名为青花椒碱(scllinifoline),结晶Ⅴ的结构待定。青花椒碱经药理试验,表明有选择性抑菌作用,对革兰氏阳性菌抑制作用较强。Five compounds have been isolated from the Chinese traditional drug Qinghuajiao (Zanthoxylum schinifolium Sieb et Zucc ). On the basis of UV, IR, ~1HNMR, ^(13)CNMR, ~1H-~1H COSY, ~1H-^(13)C COSY, NOESY and MS spectroscopic analysis, four of them have been identified as bergarpten (Ⅰ), umbelliferone (Ⅱ), skimmianine (Ⅲ) and schinifoline (Ⅳ) respectively . The compounds Ⅱ , Ⅲ and Ⅳ were obtained for the first time from Zanthoxylum schinifolium, and the last one is a new compound.

关 键 词：青花椒 茵芋碱 中药 

分 类 号：R282.710.5[医药卫生—中药学]