癫痫患者血清和脑脊液神经元特异性烯醇化酶的测定  

Serum and cerebrospinal fluid levels of neuron-specific enolase in epileptic patients

作　　者：徐建洋[1] 宋波[2] 李洪亮[1] 马天杰[3] 王守勇[1] 陈汇[2] 

机构地区：[1]江苏淮安市第三人民医院神经内科,223001 [2]江苏淮安市第三人民医院检验科,223001 [3]江苏淮安市第三人民医院麻醉科,223001

出　　处：《中华神经科杂志》2002年第3期144-146,共3页Chinese Journal of Neurology

摘　　要：目的　探讨癫痫发作对脑神经元的损伤。方法　应用酶联免疫反应法动态测定癫痫发作后患者血清和脑脊液 (CSF)中神经元特异性烯醇化酶 (NSE)的含量。结果　癫痫组血清和CSF中NSE含量在发作后明显升高 ,血清NSE水平在发作后第 1天最高 ,1周左右开始下降 ,2周左右降至正常 ;抽搐发作及频繁发作时 ,血清和CSF中NSE升高更明显。结论　癫痫发作引起血清和CSF中NSE水平的升高 ;癫痫发作导致神经元损伤 ,抽搐发作及频繁发作时神经元损伤更严重。Objective To explore neuronal damage in epileptic patients after seizures.Methods The serum and cerebrospinal fluid (CSF) levels of neuron-specific enolase (NSE) in the epileptic patients were dynamically determined after seizures by enzyme-linked immuno-sandwich assy. Results The serum and CSF levels of NSE in the epileptic patients were markedly increased after seizures. The serum levels of NSE peaked 1 day after seizure, decreased about one week later,and then returned to normal after two weeks or so. The serum and CSF levels of NSE were much higher in the epileptic patients with tic or frequency.Conclusion NSE in serum and CSF could reach higher levels after seizures, suggesting that neuronal damage may result from seizures,especially when tic and frequency occur.

关 键 词：测定 癫痫 磷酸丙酮酸水合酶 脑脊髓液 

分 类 号：R742.1[医药卫生—神经病学与精神病学]