兰索拉唑与法莫替丁治疗反流性食管炎疗效的比较  

Comparison of efficacy of lansoprazole and famotidine in treatment of patients with reflux esophagitis

作　　者：袁晓琴[1] 曹克升[2] 秦为群[3] 

机构地区：[1]上海建工医院内镜室,上海200083 [2]华东医院消化科,上海200040 [3]上海建工医院消化科,上海200083

出　　处：《药学服务与研究》2002年第2期99-101,共3页Pharmaceutical Care and Research

摘　　要：目的:比较兰索拉唑、法莫替丁治疗反流性食管炎的疗效。方法:将上海建工医院1999年1月～2000年12月间,经临床以及胃镜检查确诊的反流性食管炎病人46例随机分为兰索拉唑组及法莫替丁对照组,病人同时口服胃动力药西沙必利。治疗两个月后胃镜复查,观察疗效及不良反应。结果:兰索拉唑治疗组症状改善有效率为95.7％,法莫替丁对照组症状改善率60.6％。内镜观察食管炎改善有效率兰索拉唑组为91.3％,法莫替丁组52.2％。经Radit和秩和检验,两组症状改善和内镜观察食管炎改善的差异有显著性（P<0.01、P<0.001）。结论:兰索拉唑治疗反流性食管炎疗效明显优于法莫替丁。病人应首选质子泵抑制剂,以提高治愈率,改善生活质量。Objective: To compare the efficacy of lansoprazole and famotidine in treatment of patients with relux esophagitis. Methods: Forty-six patients diagnosed by clinical manifestations and endoscope as reflux esophagitis were divided into 2 groups. Each patient received lansoprazole or famotidine, and oral cisapride. After treatment for 2 months, the effect and drug side reaction were observed. Results: In lansoprazole group, the clinical symptomatic improving rate was 95.7% and esophagitis healing rate was 91.3%, while in famotidine group, those were 60. 6% and 52.2%, respectively. The difference was significant (P<0. 01, P<0. 001), Conclusion: Lansoprazole is obviously better than famotidine in treatment of patients with reflux esophagitis.

关 键 词：反流性食管炎 疗效 兰索拉唑 法莫替丁 对比分析 RE 

分 类 号：R571[医药卫生—消化系统] R975.2[医药卫生—内科学]