TGFβ1、TβRⅠ和TβRⅡ在膀胱癌中表达的临床及病理意义  

Clinical and pathological significance of transforming growth factor β1 and its related receptors expressed in human bladder transitional cell carcinomas

作　　者：姚欣[1] 张莉[1] 刘岩雪[1] 陈华[1] 李文录[1] 畅继武[2] 马腾骧[2] 

机构地区：[1]天津医科大学附属肿瘤医院盆腔泌尿科,天津300060 [2]天津泌尿外科研究所,天津300211

出　　处：《中国癌症杂志》2002年第3期227-230,共4页China Oncology

摘　　要：目的 :探讨转化生长因子 β1(transforminggrowthfactorβ1,TGFβ1)及其相关受体蛋白表达与人膀胱移行细胞癌 (TCCs)生物行为特征的关系。方法 :采用免疫组化方法检测 74例TCCs中TGFβ1及其受体TβRⅠ、TβRⅡ和PCNA蛋白表达。结果 :TGFβ1、TβRⅠ和TβRⅡ在TCCs中表达阳性率分别为 89.2 %、70 .3%和 4 8.6 % ,浸润性生长的膀胱癌TGFβ1过表达率为 83.8% ,明显高于表浅性生长组 (33.3% ) (P <0 .0 5 ) ;TGFβ1过表达与TCCs术后复发有关 (P <0 .0 5 ) ;TGFβ1表达强度与PCNA指数呈显著正相关 (P <0 .0 0 5 ) ;TβRⅡ阳性表达与TCCs浸润程度负相关 (P <0 .0 0 5 ) ,TGFβ1及其受体的共同表达与TCCs浸润程度有密切关系 (P <0 .0 0 5 )。 结论 :TGFβ1在TCCs的发生、发展过程中发挥双向调节作用 ,其负性调节作用的丧失与TβRⅡ失表达有关 ;TGFβ1过度表达与肿瘤细胞增殖、浸润性生长、复发等生物学行为关系密切 。Purpose:To investigate the relationships between the biological behavior of human transitional cell carcinomas(TCCs) and the protein expression of transforming growth factor β1(TGFβ1) as well as its'related receptors.Methods:The expression of TGFβ1 ,TβRⅠ,TβRⅡ and PCNA were examined in 74 specimens of TCCs by S P immunohistochemistry staining.Results:The positive expression rate of TGFβ1 , TβRⅠ and TβR Ⅱ were 89.2%,70.3% and 48.6%,respectively. Superficial tumors had lower overexpression rate of TGFβ1 (33.3%) than muscle invasive TCCs (83.8%) ( P <0.05). Significantly higher overexpression rates of TGFβ1 were observed in recurrent TCCs than in tumor free survival TCCs ( P <0.005). There existed an obvious relationship between the expressive intensity of TGFβ1 and PCNA index ( P <0.005). The expression of TβRⅡ and the co expression of TGFβ1, TβRⅠ and TβRⅡ were negatively related with the invasive depth of TCCs, significant at P <0.005.Conclusions:TGFβ1 plays as a bifunctional regulator role during the occurrence and development of human TCCs. The loss of TGFβ1's negative regulation in TCCs is related with the negative expression of TβRⅡ. The expression level of TGFβ1 is related significantly with the cell proliferation, invasive growth, and recurrence of TCCs. It could be an effective prognostic factor for patients with TCCs.

关 键 词：TGFΒ1 TβRⅠ TβRⅡ 膀胱移行细胞癌 转化生长因子Β1 PCNA 免疫组化 

分 类 号：R737.14[医药卫生—肿瘤]