高剂量亚叶酸钙、氟尿嘧啶与草酸铂治疗晚期难治性结直肠癌  

Biweekly regimen of high-dose leucovorin, fluorouracil and oxaliplatin for advanced and refractory colorectal cancer

作　　者：陆建伟[1] 潘良熹[1] 黄富麟[1] 郑秀立[1] 

机构地区：[1]江苏省肿瘤防治研究所内科,江苏南京210009

出　　处：《中国癌症杂志》2002年第3期242-244,共3页China Oncology

摘　　要：目的 :研究高剂量亚叶酸钙 (CF)、氟尿嘧啶 (5 FU)与草酸铂 (OXA)二周方案治疗晚期难治性结直肠癌的临床疗效。方法 :采用高剂量CF、5 FU、OXA深静脉输注方案 ,化疗方案以 14天为 1周期 ,重复 4周期后间隔1个月评定疗效。结果 :全组 2 8例 ,总有效率为 39.2 8%。直肠癌和结肠癌的有效率分别分 33.33% (4/ 12 )和 4 3.13% (7/ 16 )。缓解期为 2～ 2 4个月 ,中位缓解期为 5 .0个月。全组病例、PR病例、治疗无效病例的中位生存期分别为 7.0个月、11.0个月、7.0个月。PR病例的中位生存期明显好于无效病例 (P <0 .0 5 )。II、III度口腔炎发生率为 2 1.4 4 % ,5例出现手足综合征 (手足脱皮、肢端麻木、皮肤色素沉着 ) ,血液学毒性轻微。结论 :高剂量CF、5 FU。Purpose:To evaluate the efficacy and toxicity of the biweekly regimen of high dose leucovorin (CF), continuous central venous infusion(ccvi) of fluorouracil (5 FU) and oxaliplatin (OXA)for advanced and refractory colorectal cancer.Methods:28 patients (12 in rectum,16 in colon) received biweekly CF/5 FU/OXA (CF: 200 mg/m 2,ccvi 2 hour,days 1～2;5 FU:400mg/m 2,iv.,day 1; 5 FU: 1.6 g/m 2,ccvi.22 hours, days 1～2; OXA: 135 mg/m 2,ccvi.4 hour,day 1,every two weeks).Four treatment courses were carried out with an interval of one month.Results:The overall response rate was 39.28%.The response rates of rectal,colonic cancers were 33.33%% and 43.13%, respectively.Median duration of 11 partial responses were 5.0 months.Median survival of all patients was 7.0 months. Median survival of responsive patients,and non responsive was 11.0 and 7.0 months,respectively( P <0.05).Grade 2 or 3 stomatitis occurred in 21.44% of patients, in 5 patients there occurred hand foot syndrome .Hematologic toxicity were minimal.Conclusions:The biweekly regimen of high dose leucovorin/5 fluorouracil and oxaliplatin has a high response rate with acceptable toxicity in patients with advanced and refractory colorectal cancer

关 键 词：直肠肿瘤 亚叶酸钙 氟脲嘧啶 草酸铂 化学治疗 结肠肿瘤 

分 类 号：R735.3[医药卫生—肿瘤]