偏头痛患者血清神经元特异性烯醇化酶水平及其意义  

A Study of Serum Neuron-Specific Enolase Level in Patients with Migraine

作　　者：丁朝兵[1] 陈东[1] 周易谦[1] 卢炳红[2] 邱亚言 唐金荣[3] 丁新生[3] 

机构地区：[1]江苏省大丰市人民医院神经内科,江苏大丰224100 [2]江苏省大丰市妇幼保健所 [3]南京医科大学第一附属医院神经内科

出　　处：《中国医师杂志》2002年第6期630-631,共2页Journal of Chinese Physician

摘　　要：目的　探讨偏头痛发作期患者血清神经元特异性烯醇化酶 (S -NSE)水平及其对脑神经元的损伤。方法　采用ELISA法对偏头痛发作期 2 9例、间歇期 2 9例及正常人 33例s -NSE进行测定。结果　偏头痛发作期组s-NSE均显著高于其他两组 (P <0 0 1) ;间歇期组与对照组比较无显著差异。结论　偏头痛发作期可导致s -NSE水平升高 。Objective To explore the level of serum neuron-specific enolase(s-NSE) and brain neuronal damage in the migraine patients during attack.Methods The level of s-NSE was assayed by ELISA in 26 patients with migraine during attack,23 patients with migraine at intervals and 20 normal controls .Results Content of s-NSE in migraine attack groups was significantly higher than that in the other two groups(P<0 01) ,and there was no statistical difference between levels of S-NSE in the interval group and normal control group.Conclusion Migraine attack could induce raise of the s-NSE level,which suggest that brain neuronal damage occurred in migraine seizures.

关 键 词：偏头痛 血清 神经元特异性烯醇化酶 

分 类 号：R747.2[医药卫生—神经病学与精神病学]