国人家族性胃癌三家系临床特征分析  

Clinical study of familial gastric cancer among Chinese people

作　　者：宫卫东[1] 斯晓明[1] 葛乐[1] 白俊[1] 任军[1] 

机构地区：[1]第四军医大学西京医院肿瘤中心,陕西西安710033

出　　处：《第四军医大学学报》2002年第11期1011-1013,共3页Journal of the Fourth Military Medical University

基　　金：国家教育部高等学校优秀青年教师教学和科研奖励计划资助

摘　　要：目的　分析家族聚集性胃癌的临床特点 ,对家族性或遗传性胃癌患者及其家族成员进行相应的临床、实验室检查、健康咨询服务及对罹患胃癌有一定风险性的成员应采取必要的预防措施提出具体建议 .方法　回顾分析了第四军医大学西京医院 1982 - 0 1/ 1999- 0 6确诊的 14 0 2例住院胃癌患者 ,从中筛选出资料比较完整的 3个胃癌家系 .参照遗传性胃癌国际协作组《筛选遗传性胃癌最低标准》(InternationalCollaborative Group on Hereditary Gastric Cancer,ICG-HGC) ,结合实际病例调查状况制订了胃癌家系筛选标准 :1一家系中至少有 3名直系成员罹患胃癌 ;2至少有连续的 2代受累 ;3至少有 1名成员发病年令不超过 5 0岁 (≤ 5 0岁 ) .以上 3点符合其中任 2点即中选 .结果　通过调查发现共有7例患者的家系符合上述自定标准 ,占同期病例的 0 .5 75 % .其中有 3家系资料完整 ,并进行了临床特征 (如病史、临床表现、发病年龄、胃癌部位及病理等 )分析 .结论　胃癌有家族性倾向 。AIM To suggest a new conception of familial gas tric carcinoma and analyze the clinical characteristics of familial gastric carcinoma, meanwhile to givesome advices on physical examination, experimental testing, healthy counselling and surveillance these patients as well as those at risk familial members. METHODS 1402 hospitalized cases with gastric carcinoma during 1982 and 1999 were reviewed at Xijing Hospital, from which 3 families with an inclination of familial cluster were chosen. The criteria for recruiting such families were made by referring International Collaborative Group on Hereditary Gastric Cancer (ICG HGC): at least 3 relatives should have gastric carcinoma; at least two successive generations should be affected; and in one of the relatives gastric cancer should be diagnosed before age 50. Cases which fulfilled two of the above three criteria should be chosen. RESULTS There were seven familial gastric carcinoma kindred, accounting for 0.576% among those patients with gastric carcinoma during the same period. Three kindred had relative complete clinical data, with which we made an analysis of clinical characteristics and other relative problems. CONCLUSION Gastric cancer displays the trend of familial clustering. Family members susceptible to gastric cancer should be under investigation.

关 键 词：家族性胃癌 临床特征分析 筛选标准 ICG-HGC 

分 类 号：R735.2[医药卫生—肿瘤]