氧化砷对小鼠腹水型肝癌细胞的作用  

The Effect of Arsenic Trioxide on the Ascitic-type Hepatic Carcinoma Cells in Mice

作　　者：沈健[1] 吴敏华[1] 陈铭华[1] 郑瑞明[1] 沈忠英[1] 

机构地区：[1]汕头大学医学院病理学教研室,广东汕头515031

出　　处：《汕头大学医学院学报》2002年第2期68-70,共3页Journal of Shantou University Medical College

基　　金：广东省中医药局资助课题 ( 10 0 0 83)

摘　　要：目的 :研究氧化砷对移植性腹水型肝癌细胞的抗癌作用。方法 :肝癌细胞 (1 8× 10 7)接种入小鼠腹腔。对照组注射NS(0 8mL) ,余组用氧化砷 (1,2 ,3μmol/L)腹腔注射 ,每日 1次 ,共 10日。结果 :第 10天腹水细胞计数 ,1,2和 3μmol/L组瘤细胞锐减 (P <0 0 5 ) ,但第 16天腹水肿瘤细胞急骤增加。结论 :氧化砷对腹水肿瘤细胞有暂时抑制作用。Objective: To study the anticancerous action of arsenic trioxide (As 2O 3) on transplantated ascite hepatic carcinoma cells. Methods: The hepatic carcinoma cells(1.8×10 7)were inoculated into the intraperitoneal cavity of mice. NS(0.8mL)was injected in control group.As 2O 3 in 1, 2, 3μmol/L was injected into the intraperitoneal cavity respectively once a day for 10 days in other groups. Results: Ascitic_type tumor cells were calculated at the 10th and 16th day. As 2O 3 in 1, 2, 3μmol/L induced a marked decrease in the number of tumor cells at the 10th day (P<0.05), but increased sharply at the 16th day. In the 1μmol/L As 2O 3 group, tumor cell numbers slightly increased. Conclusion: Arsenic trioxide can inhibit cell growth temporarily in ascitic_type hepatic carcinoma cells

关 键 词：氧化砷 腹水型肝癌细胞 小鼠 抗癌机制 细胞形态学 细胞周期 

分 类 号：R735.7[医药卫生—肿瘤]