大蒜素包膜支架对犬冠状动脉损伤后再狭窄的影响  

Effects of Allitridin-Coated Stents on Restenosis After Prior Coronary Artery Lesions in Dogs

作　　者：聂晓敏[1] 江洪[1] 李庚山[1] 李晓艳[1] 蒋学俊[1] 王晓红[1] 漆曙辉[1] 杨新红[1] 吴钢[1] 朱中生[1] 许辉[1] 

机构地区：[1]武汉大学人民医院心内科,湖北省武汉市430060

出　　处：《中国循环杂志》2002年第3期229-231,共3页Chinese Circulation Journal

基　　金：湖北省"九.五"攻关项目(962P1101)

摘　　要：目的 :评价一种新型包膜支架携带和释放大蒜素的能力 ,并观察大蒜素包膜支架对术后再狭窄的影响。方法 :选取 6只犬 ,将大蒜素包膜支架和对照支架分别置入左回旋支的远端 (大蒜素支架组 ,n =6)和近端 (对照组 ,n =6) ,于支架置入术后 1个月行冠状动脉造影后处死 ,光镜下观察内膜增生情况。另选取 10只犬 ,分别于大蒜素包膜支架置入后 1h、1d、3d、10d和 2 8d处死 ,用高效液相色谱法测血管局部的大蒜素浓度。结果 :大蒜素包膜支架置入体内 1h、1d、3d、10d、2 8d时的血管壁浓度分别为 80 83、67 5 0、11 79、0 3 3、0 2 6ng/mg组织。术后 1个月 ,大蒜素支架组和对照组血管的损伤程度相同 ,大蒜素支架组的血管内膜增生和再狭窄程度明显低于对照组。结论 :血浆包膜支架可有效携带和释放药物 ,大蒜素包膜支架可抑制术后再狭窄发生。Objective:This study was sought to evaluate the capacity and efficacy of allitridin carried and released by a novel plasma coated stent. Methods:Ten dogs were killed at 1 h, and 1, 3, 10 and 28 days after the allitridin coated stent implantation, respectively. The concentrations of allitridin in stented vessels were determined by high performance liquid chromatography (HPLC). Additional 6 dogs were euthanized after coronary angiography and 1 month after stenting to observe neointima hyperplasia by light microscopy. Results:Allitridin concentrations in stented vessels were 80 83,67 50,11 79,0 33 and 0 26 ng/mg tissue at 1h and 1, 3, 10 and 28 days after stent placement, respectively. One month after stenting, the extent of vascular damage was similar for allitridin stent group and control group, but the angiographic coronary restenosis and the rate of neointimal proliferation were significantly less in the allitridin stent group than in the control group. Conclusions:The plasma coated eluted stents could effectively carry and release drugs at least for 28 days. The allitridin coated stents can inhibit restenosis after stent implantation.

关 键 词：大蒜素 包膜支架 犬 冠状动脉损伤 再狭窄 血管成形术 基础研究 实验研究 

分 类 号：R654.2[医药卫生—外科学]