nm23基因在下咽癌中的表达及其意义  

Expression and significance of nm23 gene in hypopharyngeal carcinoma

作　　者：李琦[1] 李湘平[1] 姚连生[1] 

机构地区：[1]第一军医大学南方医院耳鼻喉科,广州510515

出　　处：《广东医学》2002年第7期683-684,共2页Guangdong Medical Journal

摘　　要：目的　探讨nm2 3基因与下咽癌组织生物学行为之间的相关性。方法　运用免疫组化二步法检测下咽癌组织中nm2 3单克隆抗体的表达。结果　 3 6例下咽癌组织中nm2 3蛋白表达阳性率为 64 %。nm2 3蛋白表达在高、低分化肿瘤中差异有显著性 (P <0 0 5 ) ,并且在发生颈淋巴结转移的肿瘤中其阳性率明显低于未发生淋巴结转移者 (P <0 0 5 )。而与肿瘤的临床分期无明显关系 (P >0 0 5 )。结论　nm2 3基因可能具有抑制下咽癌淋巴结转移的作用。Objective To study the correlation between nm23 gene and the biological behavior of hypopharyngeal carcinoma. Methods Two-step immunohistochemical method was used to examine the expression of nm23 in hypopharyngeal carcinoma tissues. Results The positive rate of nm23 in 36 hypopharyngeal carcinoma tissues was 64%(23/36). The difference in expression of nm23 in higher and lower differentiation carcinoma was significant( P <0 05). The positive rate in carcinoma with cervical lymph node metastasis was much lower than those without cervical lymph node metastasis( P <0 05). The positive staining was not correlated to the clinical stagings( P >0 05). Conclusion nm23 gene may restrain lymph node metastasis in hypopharygeal carcinoma.

关 键 词：免疫组织化学 NM23基因 下咽癌 基因表达 

分 类 号：R739.63[医药卫生—肿瘤]