黄连素对离体灌流心脏的能量保存作用  

Effect of Energy Preservation of Berberine on Isolated Perfuse Heart

作　　者：周祖玉[1] 孙爱民[2] 徐建国[1] 蓝庭剑[1] 

机构地区：[1]四川大学基础医学与法医学院生理教研室,成都610041 [2]四川大学分析测试中心

出　　处：《华西医科大学学报》2002年第3期431-433,共3页Journal of West China University of Medical Sciences

基　　金：四川省科委科研基金资助 (基金编号G9710 4)

摘　　要：目的　研究黄连素对心衰心脏的能量保存作用。方法　采用 L angendorff逆行灌流大鼠离体完整心脏的方法以维那帕米建立心衰模型 ,比较心衰和用黄连素以后再心衰心肌的高能磷酸化合物含量的变化。结果　黄连素在一定程度上能使心衰发生时心肌的高能磷酸化合物贮存量增加。结论　黄连素对心衰具有能量保存作用。Objective To explore the effect of energy preservation of berberine on failure heart. Methods Verapamil was used to establish the heart failure model. The concentrations of high energy phosphate in the myocardium between the failure hearts with and without pre-treatment of berberine were compared. Results Berbering increased the concentration of high energy phosphate in the failure heart. Conclusion Berberine has the effect of energy preservation on heart failure.

关 键 词：黄连素 衰竭心脏 能量保存 

分 类 号：R285[医药卫生—中药学]