兔颞下颌关节囊内损伤的病理观察  

A Histopathological Observation of the Temporomandibular Joint after Intracapsular Trauma in Rabbits

作　　者：华春清 姚隆浩[2] 王国民[2] 

机构地区：[1]江苏省盐城市第一人民医院附属第九人民医院口腔医学院口腔科,江苏盐城224001 [2]上海第二医科大学口腔颌面外科,上海200011

出　　处：《上海口腔医学》2002年第2期121-124,共4页Shanghai Journal of Stomatology

摘　　要：目的探讨颞下颌关节(TMJ)囊内损伤的病理特征及其转归。方法3～4月龄新西兰白兔28只,分为6个实验组和1个对照组。首先造成兔双侧TMJ间接性损伤,然后分别于伤后1d、3d、1周、2周、1月、3月时处死,完整切除双侧TMJ,常规HE染色,病理学检查。结果实验组可见关节面骨折、关节盘和滑膜撕裂及腔内出血等,随着时间的推移,这些损伤表现出退行性骨关节病样的病理改变,但在观察期内未发现关节内粘连。结论TMJ间接性损伤可发生退行性骨关节病,并可能导致日后的关节强直。Objective To investigate the characteristics and prognosis of intra-articular trauma in the TMJ. Methods In this experiment,we used 28 young New Zealand white rabbits. They were equally dividied into 1 control group and 6 experimental groups. First，to introduce indirect trauma to bilateral rabbit TMJ. Then, we killed the animals after posttraumatic 24 hours,3 days,1 week,2 weeks, 1 month,and 3 months respectively. Finally, removed wholly the bilateral TMJs and did histopathological examinations. Results No abnormal changes were found in the control group. The experimental groups showed fracture of articular surface, avulsion of disk and synovical membrane, haemarthrosis, etc. These injuries showed pathological changes like degenerative joint disease with the time going. But, during the whole observation,we did not find any adhesion in TMJs. Conclusions Indirect injury to TMJ can result in OA, and maybe bring about the forthcoming ankylosis of TMJ.

关 键 词：颞下颌关节 间接性损伤 病理学 动物模型 退行性骨关节病 关节强直 

分 类 号：R782.6[医药卫生—口腔医学]