^(18)F-FDG分子符合探测成像在肿瘤诊断中的临床价值  

Clinical Value of Molecular Coincidence Detection with ^(18)F-FDG in the Diagnosis of Tumor

作　　者：王荣福[1] 胡怀湘[1] 范岩[1] 付占立[1] 张春丽[1] 赵光宇[1] 王彦福[1] 林景辉[1] 

机构地区：[1]北京大学第一医院核医学科,北京100034

出　　处：《中国医学影像技术》2002年第7期631-633,共3页Chinese Journal of Medical Imaging Technology

摘　　要：目的　探讨18F FDG分子符合探测 (MCD)肿瘤代谢显像应用和评价其临床价值。方法　对经组织学证实的 44例原发性肿瘤、18例转移性肿瘤和 10例肺部良性病变进行氟化脱氧葡萄糖 (18F FDG)MCD显像 ,将显像与组织学结果进行比较分析。结果　 62例肿瘤患者中 ,5 9例FDG影像示单个或多处呈不同程度异常FDG浓聚灶 ,3例未见异常FDG浓聚灶。 10例肺部良性病变FDG影像中 ,3例肺部可见异常摄取增高 ,7例未见异常FDG浓聚影。本组研究的敏感度95 .2 % ,特异性 70 % ,阳性预测值 95 .5 % ,阴性预测值 70 % ,诊断准确率 92 .1%。结论　FDGMCD/AC显像对肿瘤良恶性鉴别、分期和分级。Purpose To validate the application of 2 [fluorine 18] fluoro 2 deoxy D glucose ( 18 F FDG) molecular coincidence detection (MCD) in tumor metabolism imaging and evaluate its clinical value. Methods Forty four primary cancer, 18 recurrent cancer and 10 patients with lung benign lesions histopathologically determined were studied using 18 F FDG MCD imaging. The findings from FDG MCD/AC imaging and histological diagnosis were analyzed. Results 18 F FDG imaging results in 59 of 62 patients with cancer showed one or more marked abnormally increasing uptake of FDG, 3 cases false negative. In 10 patients with lung benign lesions, 18 F FDG images of 7 cases showed no abnormal FDG accumulation, and 3 cases false positive. In this study, the sensitivity was 95.2%, the specificity was 70%, with positive predictive value of 95.5% and negative predictive value of 70%, and the diagnostic accuracy was 92.1%. Conclusion 18 F FDG MCD/AC imaging appeared to be useful in differentially diagnosing malignant from benign lesion, tumor staging and grading, predicting therapeutic efficacy and prognosis.

关 键 词：^18F-FDG 分子符合探测成像 肿瘤诊断 临床价值 

分 类 号：R730.44[医药卫生—肿瘤]