乳腺癌^(99)Tc^m-MIBI显像与Pgp、PCNA、GST-π的关系  

Relation between Technetium-99m-MIBI Breast Cancer Imaging and Pgp, PCNA, GST-π Level

作　　者：严建[1] 蔡瑾[1] 施学莺[1] 林贾晟[1] 

机构地区：[1]上海市徐汇区中心医院核医学科,上海200031

出　　处：《中国医学影像技术》2002年第7期657-659,共3页Chinese Journal of Medical Imaging Technology

基　　金：上海市区县卫生系统学科带头人培养"百人计划"基金资助 (标号C 990 0 1 )

摘　　要：目的　探讨99Tcm MIBI乳腺显像与P糖蛋白 (Pgp)、增殖细胞核抗原 (PCNA)、胎盘型谷胱甘肽 S 转移酶 (GST π)的关系。方法　 3 9例乳腺癌患者手术前行99Tcm MIBI乳腺显像 ,术后标本病理检查并测定Pgp、PCNA、GST π水平 ,分析三者与肿瘤 /正常组织 (T/B)摄取比值和滞留分数 (RI)的关系。结果　Pgp阳性组RI明显低于Pgp阴性组 ,PCNA、GST π与T/B摄取比值和RI无明显关系。结论　计算99Tcm MIBI乳腺显像RI可以评估乳腺癌细胞的Pgp水平 。Objective To detect the relation between technetium 99m MIBI breast cancer imaging and P glycoprotein (Pgp), proliferating cell nuclear antigen (PCNA) and glutathione S transferase π (GST π). Methods Thirty nine patients with breast cancer received Tc 99m MIBI imaging before surgery. After operation, the samples of cancer were detected in pathological examination and Pgp, PCNA, GST π level, and relationship between the above three data and T/B ratio or retention index (RI) were analyzed. Results The RI was lower in Pgp positive group than Pgp negative group ( P <0.05), but there were no significant relation between PCNA, GST π and T/B ratio or RI. Conclusion Calculated retention index of Tc 99m MIBI breast imaging may evaluate the Pgp level in the breast cancer cells, and evaluate further the cells multidrug resistance.

关 键 词：乳腺肿瘤 核素显像 P糖蛋白 增殖细胞核抗原 谷胱甘肽-S-转移酶 诊断 

分 类 号：R737.9[医药卫生—肿瘤] R730.44[医药卫生—临床医学]