A Study of Factors Related to the Incidence of Cataract in Patients with Non-Insulin Dependent Diabetes Mellitus  

作　　者：Xiaoping Xia, Xiao Zhang, Haitao XiaDepartment of Ophthalmology, 3rd Clinical College, Sun Yat-sen University of Medical Sciences,Guangzhou 510630, ChinaDepartment of Ophthalmology, 1st Hospital of Nanchang City, Nanchang 330008, China 

出　　处：《眼科学报》2001年第3期180-182,共3页Eye Science

摘　　要：Purpose: To investigate the factors related to the development of cataract in patientswith non-insulin dependent diabetes mellitus(NIDDM).Methods: 792 NIDDM patients received ophthalmologic examinations including visualacuity, external status of the eyes, slit lamp microscopy and ophthalmoscopy. Glucose,urea nitrogen (BUN), creatinine (Cr), urine acid (UA), N-acetyl-β2-D-glucosaminidase(NAG), β2-microglobulin(β2-MG) and serum albumin in blood were quantitativelytested. Glucose, pH value, protein, cells, cast and ketobodies in urine were assayed.Diagnosis of cataract was based on lens opacities classification system Ⅱ. Any patientmeeting "NⅡ", "CⅡ" or "PⅡ" level was diagnosed as cataract.Results: The incidence of cataract in this group of NIDDM was 62.37 % (494/792),which significantly related to the duration of the disease course, but not to the sex of thepatient. The occurrence rate of cataract in patients suffering from NIDDM of less thanfive years duration, from five to ten years, and more than ten years was 49.67 % (228/459), 71.84 % (125/174), and 88.68 % (141/159), respectively. The occurrence ofcataract in patients diagnosed of the disease from five to ten years and more than tenyears was much higher than that of those with the course of the disease less than fiveyears( P ＜ 0.05 and P ＜ 0. 001, respectively) . Rising concentrations of blood ureanitrogen, creatinine, glycosylated hemoglobin HbA1c(G-HbA1c), N-acetyl-β2-D-glucosaminidase(NAG) and β2-microglobulin(β2-MG) indicated malfunction of thekidneys, and the rate of cataract occurrence in these patients was higher.Conclusion: This study indicates that prolongation of the duration of non-insulindependent diabetes mellitus, renal dysfunction, as well as poor blood glucose control,may accelerate the development of cataract.Purpose: To investigate the factors related to the development of cataract in patients with non-insulin dependent diabetes mellitus (NIDDM).Methods: 792 NIDDM patients received ophthalmologic examinations including visual acuity, external status of the eyes, slit lamp microscopy and ophthalmoscopy. Glucose, urea nitrogen(BUN), creatinine(Cr), urine acid(UA), N-acetyl-p2-D-glucosaminidase (NAG), β2-microglobulin(β2-MG) and serum albumin in blood were quantitatively tested. Glucose, pH value, protein, cells, cast and ketobodies in urine were assayed. Diagnosis of cataract was based on lens opacities classification system II. Any patient meeting 'NII',' CII'or 'PII'level was diagnosed as cataract. Results: The incidence of cataract in this group of NIDDM was 62. 37 % (494/792), which significantly related to the duration of the disease course, but not to the sex of the patient. The occurrence rate of cataract in patients suffering from NIDDM of less than five years duration, from five to ten years, and more than ten years was 49. 67 % (228/ 459), 71. 84 % (125/174), and 88. 68 % (141/159), respectively. The occurrence of cataract in patients diagnosed of the disease from five to ten years and more than ten years was much higher than that of those with the course of the disease less than five years( P < 0. 05 and P < 0. 001, respectively) . Rising concentrations of blood urea nitrogen, creatinine, glycosylated hemoglobin HbAic(G-HbAic), N-acetyl-β2-D-glucosaminidase(NAG)and β2-microglobulin(β2-MG) indicated malfunction of the kidneys, and the rate of cataract occurrence in these patients was higher. Conclusion: This study indicates that prolongation of the duration of non-insulin dependent diabetes mellitus, renal dysfunction, as well as poor blood glucose control, may accelerate the development of cataract. Eye Science 2001; 17: 180 ~ 182.

关 键 词：非胰岛素依赖性糖尿病 白内障 危险因素 并发症 

分 类 号：R771.3[医药卫生—眼科]