酷似恶性组织细胞病的淋巴瘤(附6例临床及病理分析)  被引量:2

LYMPHOMA OF MIMICING MALIGNANT HISTIOCYTOSIS CLINICAL AND PATHOLOGICAL STUDY OF 6 CASES

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作  者:廖小梅[1] 向兵[1] 牛挺[1] 黄杰[1] 刘卫平[1] 李甘地[1] 邓承祺[1] 

机构地区:[1]华西医科大学第一附属医院,四川成都610041

出  处:《白血病.淋巴瘤》2002年第3期135-138,共4页Journal of Leukemia & Lymphoma

摘  要:目的 :探讨酷似恶性组织细胞病 (m alignant histiocytosis,MH)的淋巴瘤之临床及病理学特征。方法 :对曾确诊 MH的 6例患者临床、实验室有关指标进行分析 ;对尸检、活检病理标本采用单克隆抗体免疫组化染色、HE染色和 EB病毒 (epstein- barr virus,EBV)原位杂交 (EBER- ISH)。结果 :6例患者临床、实验室及细胞形态学酷似 MH特征。尸检示 :恶性细胞侵袭广泛 ,多中心分布不均匀。免疫表型分析 :CD+ 45RO、CD+ 3ε、CD- 2 0 、CD- 6 8,提示恶性细胞属 T细胞来源而非组织细胞来源。同时所作 3例 EBER- ISH均为阳性反应。结论 :酷似 MH的淋巴瘤其恶性细胞多来源于 T细胞。Objective:To evaluate the clinical and pathological feature of the lymphoma mimicing malignant histiocytosis (MH).Methods:The clinic and laboratory findings were analyzed from 6 cases previously diagnosed as MH. HE staining and immunohistochemical staining with monoclonal antibodies were performed on the specimens of autopsy/ biopsy. Epstein Barr virus (EBV) was examined by in situ hybridization (EBER ISH) in 3 cases.Results:In 6 cases, the clinical, laboratory and cytomorphologic features resembled MH. Autopsy showed that the infiltration of neoplastic cells was very extensive in tissues or organs, but their contribution was not uniformity. Immunophenotype studies showed that the neoplastic cells were positive for CD 45RO , CD 3ε, but negative for CD 20 , CD 68 . EBER ISH revealed positive in the almost neoplastic cells.Conclusion:The neoplastic cells of lymphoma mimicing MH derived majority from T cell lineage. Infection of EBV is likely to relate with occurrence of this type of lymphoma.

关 键 词:恶性组织细胞病 淋巴瘤 EB病毒 

分 类 号:R733.1[医药卫生—肿瘤] R733.4[医药卫生—临床医学]

 

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