统计模拟分光光度法同时测定复方茶碱片中的五组分含量  

SIMULTANEOUS DETERMINATION OF THE CONTENTS OF FIVE COMPONENTS IN COMPOUND THEOPHYLLINI TABLETS BY STATISTICAL - SIMULATION SPECTROMETRY

作　　者：黄丽[1] 阚启明[2] 王玺[2] 罗旭[2] 毕开顺[2] 

机构地区：[1]辽宁省公安厅刑科所,沈阳110032 [2]沈阳药科大学,沈阳110015

出　　处：《化学分析计量》2002年第4期11-14,共4页Chemical Analysis And Meterage

摘　　要：研究了测定复方茶碱片中五组分含量的统计模拟分光光度法。利用逐步回归分析法建立经验数学模型,再运用改良单纯形法进行优化,同时测定复方茶碱片中的五种组分——氨基比林、非那西丁、茶碱、可可碱和咖啡因的含量,其回收率分别为99.5％、100.2％、101.2％、100.2％和99.2％,RSD分别为1.51％、1.03％、4.44％、2.47％和3.12％。t检验结果证明,该方法与HPLC法之间无显著性差异。The statistical - simulation spectrometry for the determination of the contents of five components in compound theo-phyllini tablets was studied. The experiential mathematical model was built up by using stepwise regression and optimized with modifiedsimplex method, then five components-amidopyrine,phenacetine,theophylline, theobromine and caffeine in compound theophyllinitablets were determined simultaneously. The recoveries of amidopyrine, phenacetine, theophylline, theobromine and caffeine are 99.5% , 100.2% , 101.2% ,100.2% and 99. 2% respectively, the RSD are 1.51% , 1.03% ,4.44% ,2.47% and 3. 12% respectively. It was proved by t - test that there is no remarkable difference between this method and HPLC.

关 键 词：同时测定 统计模拟分光光度法 复方茶碱片 氨基比林 非那西丁 茶碱 可可碱 咖啡因 

分 类 号：R917[医药卫生—药物分析学]