胃腺癌发生过程中Fas、Bcl-2蛋白的表达变化  

Alterations of Fas and Bcl-2 Protein Expression in the Carcinogenesis of Gastric Adenocarcinoma

作　　者：贾百灵[1] 李立 雷霖 李继昌[3] 

机构地区：[1]河南省人民医院消化内科,河南郑州450003 [2]河南省医学科学院,河南郑州450003 [3]郑州大学医学院,河南郑州450052

出　　处：《中国误诊学杂志》2002年第7期980-981,共2页Chinese Journal of Misdiagnostics

基　　金：河南省科技攻关课题 (No:981 1 70 2 0 3)

摘　　要：目的　探讨 Fas、Bcl- 2基因在胃癌发生中的意义。方法　用免疫组化 ABC方法检测 4 8例胃腺癌组织 ,74例非癌胃粘膜组织。结果　不典型增生组织及癌组织中 Fas蛋白表达率较正常 ,胃粘膜上皮中显著下降 (P<0 .0 5 )。中、高分化胃癌中 Fas蛋白阳性表达率显著高于低分化癌 (P<0 .0 5 ) ,而 Bcl- 2阳性表达在高分化癌中显著低于低分化癌 (P<0 .0 5 )。本组 Fas和 Bcl- 2呈负相关 (P<0 .0 5 )。结论　 Fas、Bcl- 2蛋白表达变化发生在胃粘膜癌变的早期阶段 ,并与胃癌的进展及预后密切相关。Objective To study the role of Fas?Bcl -2 gene in the carcin ogenesis of gastric adenocarcinoma.Methods The expression of Fa s?Bcl-2 prote in in the Cancer tissues from 48 patients and noncarcirous tissues from 74 patie nts were detected with immunohistochemical method.Results The e xpression of Fas protein in dysphasia and Cancer tissue decreased significantly as compared to t hat in the normal epithelia(P<0.05).The expression in cancer of grade Ⅲ was higher than that in cancer of grade Ⅰ(P<0.05 ).The expressions of Fas and Bcl-2 protein were closely related(P<0.05).Conclusion The alterations of Fas and Bcl-2 prote in were presen t early in Carcinogenesis of gastric adenocarcinoma,and might be closely relate d to the progress and prognosis of the Cancer.

关 键 词：胃腺癌 胃肿瘤 病理学 CD95抗原 FAS基因 BCL-2基因 免疫组织化学 基因表达 

分 类 号：R735.2[医药卫生—肿瘤]