单一和四联疗法根除幽门螺杆菌对果胶铋吸收和代谢的影响  

The difference of the bismuth absorption from a single colloidal bismuth pectin therapy and quadruple therapy for eradicating Helicobacter pylori infection

作　　者：张澍田[1] 张松华[1] 于中麟[1] 王永芳[2] 

机构地区：[1]首都医科大学附属北京友谊医院消化科,100050 [2]卫生部食品卫生监督检验所

出　　处：《中华医学杂志》2002年第13期872-874,共3页National Medical Journal of China

摘　　要：目的　通过对根除幽门螺杆菌 (Hp)单一、四联用药时大鼠血铋浓度的监测和停药后其重要脏器 (心、脑、肾、肝 )中铋蓄积量的检测 ,明确四联用药是否影响果胶铋中铋的吸收。方法　将体重 4 0 0～ 5 0 0g的 2 4只雄性Wistar大鼠随机分为两组 :A1组 :单用果胶铋 (CBP) ;A2 组 :果胶铋四联〔CBP +阿莫西林 (AMO) +甲硝唑 (MTR) +兰索拉唑 (LAN)〕 ,检测喂药前、后 1、2、3、4、5、6h不同时间点的血铋浓度 ;将体重 2 0 0～ 2 5 0g的 2 4只雄性Wistar大鼠随机分为两组 :B1组 :单用CBP ;B2 组 :果胶铋四联 (CBP +AMO +MTR +LAN) ,每日各喂药 1次 ,共 14d ,检测停药 8周后心、脑、肾、肝组织中铋蓄积量。结果　一次喂药后A2 组血铋浓度达峰时间较A1组提前约 1h ;停药 8周后 ,B1、B2 组心、脑、肾、肝内均有铋沉积 ,以肾内蓄积量最多 ,B1与B2 组肾内蓄积量 (15 4± 15ng/gvs 2 12± 2 0ng/g)差异有显著意义 (P <0 .0 5 )。结论　根除Hp四联疗法促进果胶铋中铋吸收 ,增加铋在肾脏中的蓄积 ,若需长期服用 ,应监测其安全性。Objective To investigate whether the quadruple therapy influences the absorption of bismuth from Colloidal Bismuth Pectin (CBP). Methods 24 male Wistar rats weighing from 400 g to 500 g were randomly divided into two groups: CBP group (group A 1) and CBP+AMO+MTR+ LAN group (group A 2). The serum bismuth concentration was observed at 0,1,2,3,4,5,6 hour after these medicines were fed. Other 24 male Wistar rats weighing from 200 g to 250 g were randomly divided into two groups: CBP group (group B 1), CBP+AMO+MTR+LAN group (group B 2). These medicines had been taken every day for 14 days. The accumulation of bismuth in the heart, brain, kidney and liver of rats were detected eight weeks later. Results The serum peak value of bismuth is not significantly different between group A 1 and group A 2 ( P >0.05), but the peak time of bismuth of the group A 2 is one hour earlier than that of group A 1. The amounts of the accumulation of bismuth in the kidney are 154±15 ng/g and 212±20 ng/g in the group B 1 and B 2 respectively at the eighth week after the medicines were fed in rats with a significant difference ( P <0.05). Conclusion The quadruple therapy causes an increase of the absorption and the accumulation of bismuth from CBP in the kidney in rats.

关 键 词：幽门螺杆菌 果胶铋 吸收 代谢 药物疗法 铋 肾脏 四联用药 血铋浓度 动物实验 

分 类 号：R570.5[医药卫生—消化系统]