抗心磷脂抗体与脑卒中关系的研究及其临床意义  

The Study of the Relationship between Anti-cardiolipin Antibodies and Stroke with Clinical Significance

作　　者：徐旭日[1] 邢振华[1] 付玲[1] 

机构地区：[1]山东省青岛市立医院神经科,山东青岛266011

出　　处：《中国神经免疫学和神经病学杂志》2002年第3期142-144,共3页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的　探讨抗心磷脂抗体 (anti-cardiolipin antibodies,ACA)与脑卒中的关系及其临床意义。方法　应用ELISA法对脑梗死患者 1 0 4例短暂性脑缺血发作患者 2 7例、脑供血不足患者 41例、脑出血患者 3 3例进行了ACA检测 ,并与 1 0 0例健康者进行对照。结果　脑梗死组与对照组比较差异有极显著性 (P <0 .0 1 ) ,且提示ACA中 Ig G型与临床密切相关。另外 ,发现 ACA阳性与青壮年脑梗死关系更为密切 ,以多发性脑梗死更为多见。结论　ACA可作为脑梗死危险性增加的指标。Objective To explore the clinical significance of the relationship between anti cardiolipin antibodies and stroke.Methods In this study, the positive rate of ACA in plasma of 104 patientswithcerebral infarction, 27 with TIA ,41 with cerebral blood flow defieciency, 33 with cerebral hemorrhage, and 100 normal subjects were evaluated by ELISA methods.Results the positive rate of ACA in patients with cerebral infarction was highly significant statistically (P<0 01). We suggested that IgG type ACA may have some clinical value with these patients. Also, we noticed that ACA positive was more relevant to stroke in young adults and the incidence of multi infarction was more common on ACA positive strokes.Conclusions ACA can be served as an indicator of an increased severity of cerebral infarction.

关 键 词：抗心磷脂抗体 脑卒中 酶联免疫吸附试验 脑梗死 ACA ELISA法 相关性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]