胰激肽原酶治疗早期糖尿病性视网膜病变的初步研究  

Primary study of Pancreatic Kininogenase Tablets treating primary diabetic retinopathy

作　　者：韩梅[1] 陈松[1] 张树丽[1] 时冀川[1] 王兰惠[1] 

机构地区：[1]天津市眼科医院,300040

出　　处：《临床眼科杂志》2002年第3期198-201,共4页Journal of Clinical Ophthalmology

摘　　要：目的　探讨早期糖尿病性视网膜病变 (diabetic retinopathy,DR)对视盘及黄斑部视网膜血流的影响及与吲哚青绿血管造影 (indocyanine green angiography,ICGA)中黄斑部脉络膜血管充盈时间 (choriocapillaris fill-ing phase,CFP)、黄斑中心凹无血管区 (foveal avascular zone,FAZ)的关系 ,评价胰激肽原酶肠溶片 (pancreatickininogenase tablets,商品名 :怡开 )对视盘及黄斑部视网膜血流动力学的影响。方法　对 30例 (6 0只眼 )早期 DR及 49例 (98只眼 )正常对照组进行 ICGA与荧光素血管同步造影及共焦扫描激光多普勒视网膜血流分析仪 (hei-delberg retina flowmeter,HRF)检查。结果　早期 DR组的视盘及黄斑部视网膜的血流量、流速及红细胞移动速率均低于正常对照组 ,二者差异有非常显著性意义 (P <0 .0 1) ;经怡开治疗后视盘及黄斑部视网膜的血流量、流速及红细胞移动速率均较治疗前有显著或非常显著性意义 (P <0 .0 1或 P <0 .0 5 ) ;CFP与黄斑视网膜的血流量、流速及红细胞移动速率呈负显著相关 (P <0 .0 5 )。结论　早期 DR视盘及黄斑部视网膜毛细血管血流已发生改变 ,怡开可能改善 DR患者的微循环障碍 。Objective To study that primary diabetic retinopathy(DR)affect blood flow of optic and macular retina,and in relation to choriocapillaris filling phase(CFP),foveal avascular zone(FAZ)in indocyanine green angiography(ICGA).To evaluate change of blood flow of optic and macular retina after Pancreatic Kininogenase Tablets treating.Methods 30 patients(60 eyes)of DR and 49 control subjects(98 eyes) undertook ICGA,FFA and Heidelberg Retina Flowmeter(HRF).Results The blood flow volume(VOL),blood flow velocity(FLW)and the erythrocyte flow velocity(VEL)of optic and macular retina of DR were lower those of control subject(P<0.01).VOL,FLW and VEL of optic and macular retina after treating have obvious difference to compare with those before treating(P<0.01 or P<0.05).CFP was negative relation with VOL,FLW adn VEL of optic and macular retina (P<0.05).Conclusion The blood flow of optic and macular retina already change in primary DR.PKT maybe improve microcirculation disturbance.HRF can evaluate curative effect.

关 键 词：胰激肽原酶 早期糖尿病性视网膜病变 治疗 视网膜血流 吲哚青绿血管造影 

分 类 号：R774.1[医药卫生—眼科]