维生素B_6对地塞米松诱导大鼠腭裂形成影响的实验研究  

Experimental study on effects of vitamin B_6 on dexamethason-induced palatal cleft formation in the rat

作　　者：张诗雷[1] 袁文化[1] 

机构地区：[1]第二医科大学口腔医学院唇腭裂治疗中心,上海200011

出　　处：《中华口腔医学杂志》2002年第4期272-274,I002,共4页Chinese Journal of Stomatology

摘　　要：目的　探讨维生素B6(VitB6)是否有预防腭裂发生的作用。方法　在妊娠第 14、15天给予经地塞米松 (Dexamethason ,DEX)致畸的孕鼠肌肉注射 10mg/kg体重VitB6,比较其胎鼠与单纯以DEX致畸胎鼠的腭裂发生率及腭裂类型构成。结果　实验组胎鼠腭裂发生率 (32 35 % )显著低于单纯以DEX致畸的对照组胎鼠 (6 4 5 2 % ) ,畸形的程度亦有所减轻。结论　DEX致畸前及致畸同时补充足够的VitB6能显著减少大鼠胚胎的腭裂发生率 ,并减轻了畸形的程度。提示VitB6对预防腭裂畸形的发生可能具有一定的价值。Objective To evaluate whether or not administration of vitamin B 6(vitB 6) has preventive effects on cleft palate formation. Methods On the 14?15 day of gestation,the pregnant rats were treated with administration of vitB 6(10 mg/kg weight im)before and simultaneously with dexamethason (DEX). Compared the palatal cleft incidence of their fetuses with those whose mother were given DEX only. Results Treatment with administration of vitB 6 before and simultaneously with DEX, the palatal cleft incidence of subject group fetuses (32 35%)was significantly less than that given DEX only (64 52%). The proportion of the palatal cleft type was also changed significantly. Conclusions VitB 6 decrease both the incidence and the severity of cleft palate induced by DEX in rats, which indicates VitB 6 may have preventive effects on cleft palate formation.

关 键 词：维生素B6 地塞米松 腭裂 实验研究 

分 类 号：R782[医药卫生—口腔医学]