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作 者:郭瑞臣[1] 孙若鹏[1] 闫秀贤 崔唏[1] 王本杰[1]
机构地区:[1]山东医科大学附属医院,济南250012 [2]北京儿童科学研究所
出 处:《中国临床药理学与治疗学》1999年第1期17-20,共4页Chinese Journal of Clinical Pharmacology and Therapeutics
摘 要:目的 以咖啡因为代谢探针,研究汉族儿童N-乙酰化代谢表型分布规律及其与21-三体综合征(DS)和假肥大性肌营养不良症(DMD)相关性。方法 根据参试者尿中咖啡因代谢物5-乙酰氨基-6-甲酰氨基-3-甲基尿嘧啶(AFMU)和甲磺嘌呤(1X)峰高比的对数值(1gAFMU/1X)绘制频率分布直方图,寻找区分快、慢乙酰化代谢表型的截点,确定患儿和健康儿童的N-乙酰化代谢表型分布。结果 正常儿童乙酰化代谢表型分布直方图呈双态性,截点明显,为 0.25(lgAFMU/1X),慢乙酰化代谢表型个体为16.9%,而 DS和DMD患儿则分别为41.9%和50%(x2分别为8.287和11.387,P<0.05)。男、女和>6岁与≤6岁儿童快、慢乙酰化代谢表型分布差异无显著性。结论 汉族儿童乙酰化代谢表型分布呈多态性,与成人相似。年龄和性别对结果无显著影响。The distribution of N-acetylate phenotype in Chinese children and its relationship with Down' s syndrome(DS) and Duchenne muscular dystrophy (DMD) was investigated. Methods Thirty-one subjects with Down' s syndrome, 18 with Duchemne muscular dystrophy and 154 healthy children were acetylate-phenotyped with caffeine as a probe drug.Urine samples were collected 2 hours after administration of 60-100 ml of 10 mg/100 ml caffeine-spiked coca cola and analyzed by high performance liquid chromatography (HPLC) . The LgAFMU/ IX of peak hight ratio was used to construct the frequence histogram and probit plot and to assese slow and fast acetylator staus both in the healthy and the DS/ DMD children. Results The range of Ig AFMU/ IX in healthy children was 0.45-1.86, and in those with DS and DMD was 0.15-1.56 and 0.15-0.38 respectively. The ratio of 0.25 [Ig(AFMU/1X)] was sellected as a cut-off and used to separate slow and fast acetylators. Slow acetylators in children with DS accounted for 41.9% (13/ 31) whi le with DMD 50% (9/ 18), significantly higher than 16.9% of healthy children (X2 = 8.287, P< 0. 005 and X2=11.367, P< 0.005 respectively) .Conclusions The acetylate status is polymorphic in Chinese healthy children. Slow acetylators of children with DS or DMD were more than those of healthy children. Age and sex had no significant influence to acetylate status.
关 键 词:N-乙酰化代谢表型 多态性 21-三体综合征 假肥大性肌营养不良症 咖啡因
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