肾细胞癌病理诊断中的形态计量学研究  

Cytomorphometric study in pathologic diagnosis of renal cell carcinoma

作　　者：李玉魁[1] 王之贤[2] 王靖宇 李月明[1] 李伯全[1] 王军[1] 刘兆宽[1] 孙丽霞 王蔚 刘嵘[1] 

机构地区：[1]天津市解放军第二五四医院泌尿外科,天津300142 [2]军事医学科学院卫生学环境医学研究所,天津300050

出　　处：《中国体视学与图像分析》2000年第2期76-80,共5页Chinese Journal of Stereology and Image Analysis

摘　　要：为探讨细胞形态计量学方法在肾细胞癌病理诊断中的价值。方法　采用细胞形态计量学技术对 10 0例肾细胞癌 (RCC)及 10例正常肾组织标本进行测量分析。分析的参数包括 :核面积 ,核形态系数 ,核质比 ,核比轴 ,核短轴 ,轴率等。结果　本研究发现 :1.RCC具有明显的核异型性 ;2 .颗粒细胞癌核面积、核长轴、核短轴均大于透明细胞癌 ;3.核面积、核长轴与核短轴均与核Fuhrman分级呈高度正相关。结论 :细胞形态计量技术 ,完善了传统的单纯依靠经验进行病理诊断的方法 ,具有临床实用价值。Objective To approach the significance of cytomorpnometry in the diagnosis of renal cell carcmoma.Methods:Quantitative analyses of morphological parameters such as nuclear area(NA),nuclear shape factor(NSF),nucleus cytoplasm ratio(NCR),nucleus long axis(LA),nucleus short axis(SA),axis ratio(AR) were carried out by cytomorphometry n 100 cases with renal cell carcinoma(RCC) and 10 cases of normal renal tissue.Results (1)RCC had obvious nuclear atypia;(2)NA,LA and SA of granular cell carcinoma were lavger than those of clear cell carcinoma;(3)High positive correlations were found between nuclear parameters(NA,LA,SA)and Fuhrman gradings.Conclusion Cytomorphometry is better than tranditional pathological diagnosis by experience,and can raise the accurancy tate of diagnosis.It is worth using in clinical practice.

关 键 词：肾细胞癌 病理诊断 形态计量学 

分 类 号：R737.11[医药卫生—肿瘤]