单胺氧化酶A基因EcoR V多态与帕金森病的关联分析  

The EcoRⅤpolymorphism of human monoamine oxidase A is not associated with idiopathic Parkinson's disease in a Shanghai Han population

作　　者：谢惠君[1] 汪晓华[2] 郝怡鑫[1] 汤国梅[2] 徐玲[2] 吴奇涵[2] 陈丽珊[2] 任大明[2] 

机构地区：[1]第二军医大学附属长海医院神经内科,上海200433 [2]复旦大学遗传学研究所国家重点遗传工程实验室

出　　处：《中华医学遗传学杂志》2002年第4期329-331,共3页Chinese Journal of Medical Genetics

摘　　要：目的　研究单胺氧化酶 A(monoamine oxidase A,MAO- A)基因 Eco R 多态 (C/ T)位点在中国人群中的分布 ,并探讨其与帕金森病 (Parkinson's disease ,PD)发病风险的关系。方法　采用聚合酶链反应 -限制性片段长度多态性分析法 ,在 110例 PD患者和 182名正常人中分析了 MAO- A基因 Eco R (C/ T)多态的分布 ,并对该多态与 PD进行关联分析。结果　 (1) MAO- A基因 Eco R 多态与 PD间不存在明显关联 (χ2 =0 .0 91,P=76 .3) ;(2 ) MAO- A基因 Eco R 多态在中国汉族人群和北美高加索人群中的分布差异有显著性 (χ2 =30 .0 3,P=4 .18)。结论　 MAO- A Eco R 多态可能与中国人Objective To explore the distribution of monoamine oxidase A (MOA A) EcoRⅤpolymorphism in Shanghai Han population and its possible role in the risk for Parkinson's disease(PD). Methods The MAO A gene EcoRⅤ polymorphism was detected with PCR RFLP method in 110 PD patients and 182 healthy controls, furthermore, statistical analysis was performed to investigate association between EcoRⅤpolymorphism and PD onset. Results (1)Remarkable difference in MAO A EcoRⅤ polymorphic distribution has been observed between Shanghai Han population and that in North America. (2) Neither allelic frequency nor genotypic frequency in PD cases differs significantly from that in healthy controls regardless of data from male or female subclass. Conclusion There may be racial difference in the distribution of the human MAO A EcoRⅤ(C/T) polymorphism, but the present research does not support the association between this variant and susceptibility to PD in Chinese Han population of Shanghai area.

关 键 词：帕金森病 单胺氧化酶 聚合酶链反应-限制性片段长度多态性 MDA-A PD 

分 类 号：R742.5[医药卫生—神经病学与精神病学]