应用高强度聚焦超声治疗恶性实质性肿瘤  

High intensity focused ultrasound ablation in the treatment of human malignancies

作　　者：白向君[1] 章明[1] 李伟兵[1] 王太洪[1] 吴春培[1] 包盛娣[1] 夏正瑜[1] 

机构地区：[1]江苏省肿瘤医院超声刀治疗中心,210009

出　　处：《江苏医药》2002年第8期574-576,共3页Jiangsu Medical Journal

摘　　要：目的　探讨高强度聚焦超声肿瘤治疗系统 (HIFU)的安全性、有效性及可能性。方法　应用HIFU肿瘤治疗系统对 84例恶性实质性肿瘤进行了 96次治疗。结果　 34例肝癌中 5例有疼痛的患者治疗后疼痛消失 ,术后彩超显示 34例均出现肿瘤内血供减少或消失 ,2 9例肿瘤缩小 ,回声增强 ;18例骨肿瘤、5例胰腺癌及 2 7例软组织、后腹膜、盆腔转移性肿瘤治疗后均出现肿瘤回声增强 ,临床症状改善 ,部分病例出现肿块缩小 ;84例患者治疗后复查CT、SPECT、MRI等检查均有改变 ;治疗中及治疗后患者生命体征平稳 ,除 5例出现局部皮肤烧伤外无其它并发症出现。结论　HI FU技术为临床治疗恶性实质性肿瘤提供了一个全新、安全、无创的治疗手段。Objective To explore the safety,effectiveness and feasibility of high intensity focused ultrasound (HIFU) in the treatment of patient with malignant solid carcinoma.Methods From September 2000 to September 2001,a total of 84 patients with solid malignancies underwent HIFU ablation for 96 times.Results Among the 34 patients with hepatocellular carcinoma treated by HIFU,severe pain caused by tumor in 5 patients was completely stopped after the treatment;color Doppler ultrasound imaging indicated a significant decline and disappearance in the blood flow of treated tumor area in all cases;29 patients revealed an obvious regression of treated tumor and hyperechogenicity of lesion on the ultrasound imaging.With HIFU ablation,clinical symptoms were remarkably improved in other patients including 18 cases of malignant bone tumor,5 cases of pancreatic cancer,and 27 cases of soft tissue sarcoma,pelvic and retroperitoneal metastatic tumors.Follow up CT,SPECT,MRI and color Doppler ultrasound images showed therapeutic response of treated tumor in 84 cases,and the tumor shrinkage in some of the treated patients.During and after HIFU procedure,no significant changes in treated patients blood pressure,pulse,respiratory rate,and peripheral oxygenation.No servere adverse effects were found except the skin burn that developed in five of them.Conclusion HIFU technique provides a safe,noninvasive ablation for the treatment of human solid malignancies in clinical practice.

关 键 词：高强度聚焦超声 实质性恶性肿瘤 安全性 治疗 

分 类 号：R730.59[医药卫生—肿瘤]