经动脉灌注碳酸氢钠和维拉帕米提高抗肿瘤药物疗效的初步观察  

Investigation of increased efficacy of trans-arterial infusion of HaHCO_3 and verapamil on solid malignant tumors in interventional chemotherapy

作　　者：范平生[1] 胡冰[2] 庄建生[2] 孙昕[3] 林新民[2] 季楚舒[2] 李继德[1] 汪世存[2] 白虎[1] 冯克海[1] 

机构地区：[1]安徽省立医院分院,合肥230031 [2]安徽省立医院 [3]安徽医科大学

出　　处：《中国肿瘤临床与康复》2002年第4期19-20,18,共3页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：安徽省重点科研项目资助 (No 0 1 0 2 30 2 7)

摘　　要：目的　经动脉向恶性肿瘤组织灌注碳酸氢钠和维拉帕米 ,调节恶性肿瘤细胞内外H+ 、Ca2 + 离子分布 ,观察对IL 2、IFN α 2b和ADM、MMC等介入治疗的增效作用。方法　分层随机分为单纯动脉介入化疗药物组 (A组 ) ;碳酸氢钠联合化疗药物动脉介入组 (B组 ) ;碳酸氢钠联合IL 2、IFN α2b、化疗药物介入组 (C组 ) ;碳酸氢钠、维拉帕米联合IL 2、IFN α2b介入组 (D组 ) 4个组 ,A、B、C、D4个组介入 2个疗程后判断疗效。Seldinger技术穿刺经股动脉进入肿瘤动脉血管 ,药物按一定比例稀释后灌注。结果　B组部分缓解率明显高于A组 ,D组部分缓解率均高于其它 3个组。结论　向恶性肿瘤组织灌注碳酸氢钠、维拉帕米可提高IL 2、IFN α2b、ADM。Objective To observe the increased efficacy of IL 2,ADM and MMC,by infusing NaHCO 3 and verapamil into malignant tumors and modifying distribution of H +?Ca 2+ in tumor cells.Methods Patients were divided into four groups randomly.Group A was infused with anti cancer agents alone;group B was infused with NaHCO 3 and anti cancer agents;group C with NaHCO 3,IL 2 and anti cancer agents;group D with NaHCO 3,verapamil,IL 2 and anti cancer agents.The efficacy was evaluated after two courses of arterial interventional chemotherapy in group A and B.And in group C and D the efficacy was evaluated after one course of treatment.By Seldinger technique,drugs were infused at proper concentrations in the following sequence:1.5% SB 80～100ml;2.NS 30ml;3.IL 2 40～60×10 4μ,4.ADM50～60mg;5.DDP 100mg or MMC10mg or DPT 50mg;6.5 FU 1.0～1.5;7.verapamil 10mg;8.verapamil 5～10mg in half hour.Results The partial remission (PR) in group B is significantly higher than that in group A;PR in group D is higher than those in group A,B and C.Conclusion Arterial infusion of NaHCO 3 and verapamil into malignant tumors can increase the efficacy of ADM,MMC and TL 2.

关 键 词：碳酸氢钠 维拉帕米 白细胞介素-2 阿霉素 动脉灌注 抗肿瘤药 

分 类 号：R730.53[医药卫生—肿瘤]