人胚肝低密度脂蛋白受体活性与血清胆固醇水平的关系  

The relation between liver low density lipoprotein (LDL) receptor activity and serum cholesterol levels in human fetus

作　　者：谢崇伦[1] 蔡海江[1] 陈秀英[1] 陈琪[1] 陈毓华[1] 

机构地区：[1]南京医学院病理生理教研室

出　　处：《中国病理生理杂志》1991年第3期225-228,共4页Chinese Journal of Pathophysiology

摘　　要：用卵磷脂/丙酮沉淀法测定经部分纯化的人胚肝LDL受体活性,结果发现,随着胎龄增加,肝脏LDL受体活性明显增高。与此同时,血清总胆固醇(TC)和LDL-胆固醇(LDL-C)水平进行性下降。胎龄与血清TC和LDL-C的相关系数分别为-0.80和-0.77,有显著意义(P<0.001)。进而发现,在胚肝LDL受体活性与血清TC和LDL-C之间也存在着明显的负相关,相关系数分别为-0.96和-0.95(P<0.001)。这一结果提示,在胎儿发育过程中,肝脏LDL受体对血胆固醇水平调节起着关键的作用。The activity of the solubilized receptor was assayed by precipitating the receptor with acetone in the presnce of egg phosphatidyleholine liposomes. It was found that the binding of ^(125)I-LDL to fetal liver receptors rose significantly with the increase of fetal age. During the same period, the total cholesterol (TC) and LDL-eholesterol (LDL-C) levels in fetal serum declined progressively. The correlation between fetal age and concentration of TC and LDL-C were -0.80(P<0.001) and -0.77(P<0.001), respectively. Thus, there was an inverse correlation between the liver LDL recept or activity and the serum TC (r=-0.96, P<0.001) and LDL-C (r=-0.95, P<0.001). It suggested that the LDL receptor in human fetal liver may play a key role in the regulation of the serum cholesterol levels in the fetus during gestation.

关 键 词：脂蛋白类 低度蜜 胆甾醇 胎儿 

分 类 号：R364.1[医药卫生—病理学]