国产与进口茴三硫片对口腔疾病引起口干症的疗效比较  

Effect of domestic and imported anetholtrithoines in management of xerostomia caused by the dental diseases

作　　者：周伟[1] 周正波[2] 戚向敏[3] 

机构地区：[1]山东省生物药物研究院,济南250014 [2]山东省肿瘤防治研究院,济南250117 [3]山东医科大学附属口腔医院,济南250012

出　　处：《中国临床药学杂志》2002年第4期210-213,共4页Chinese Journal of Clinical Pharmacy

摘　　要：目的 :评价进口和国产茴三硫片 (ANTT)对口腔疾病引起口干症的疗效。方法 :口腔疾病所致口干症状患者 4 0例 ,按随机表 (双盲 )分成 2组。国产组 2 0例 (男 3例 ,女 17例 ) ,年龄 (5 1± 6 )a。进口组 2 0例 (男 5例 ,女 15例 ) ,年龄 (5 0± 13)a。分别用进口或国产ANTT片 2 5mg,po ,tid× 2 8d。结果 :按可视分析标尺 (VAS)法、主观症状评价表及唾液流量 (用滤纸洇湿时间进行测定 )进行评价。用药后 ,各主、客观症状都有明显改善。治疗前后比较 ,2组各症状的改善情况有显著性差异 (P <0 0 5 ) ,2组间各症状的改善情况无显著性差异 (P >0 0 5 )。 2组均未见明显不良反应。结论AIM: To compare the effect of imported and domestic anetholtrithoines on xerostomia caused by dental diseases. METHODS: Forty patients with xerostomia were divided into 2 groups in random, Twenty patients for the domestic group (M3, F17; age 51 a±6 a). Twenty patients for the imported group (M5, F15; age 50 a±13 a). Anetholtrithions were given 25 mg, po , tid×28 d. RESULTS: The results were assessed by VAS methods, subjective questionaire and the salivary flow (determined by the time of the filter paper wetten). Subjective and objective symptoms were improved after the treatment in 2 groups. The improvement of every subjective and objective symptoms were significant difference between before and after the treatment ( P <0 05). The improvement of subjective symptoms and the time of the filter paple wetten were nonsignificant difference between 2 groups ( P >0 05). No adverse drug reactions were found in 2 groups. CONCLUSION: The domestic and imported anetholtrithions have the same effects on xerostomia caused by the dental diseases.

关 键 词：茴三硫 口腔干燥 口腔疾病 ANTT 

分 类 号：R781.05[医药卫生—口腔医学]