急性肝衰竭时肾功能障碍发生机理的探讨  

Studies on the pathogenesis of renal insufficiency in acute hepatic failure

作　　者：王蕊[1] 陈贤明[1] 韩德五[1] 许瑞令[2] 赵元昌[2] 尹镭[2] 马学惠[2] 

机构地区：[1]山西医学院病理生理教研室 [2]山西医学院肝病研究室

出　　处：《中国病理生理杂志》1991年第5期482-486,共5页Chinese Journal of Pathophysiology

摘　　要：本实验研究了半乳糖胺所致急性肝衰时内毒素血症和肾功能障碍的关系以及丹参的防治作用。实验结果表明、半乳糖胺所致肝衰的动物均伴有内毒素血症的发生、肾功能明显异常(Pcr,BUN升高,Ccr,UV,U_(Na)V降低,FE_(H2O),FE_(Na)增高)。经丹参治疗后内毒素血症明显减轻,肾功能也随之明显改善,从而提示内毒素血症和肾功能障碍密切相关。本实验结果证明,内毒素血症在肝肾综合征的发生,发展中是一个重要致病因素;丹参对肝肾综合征具有明显的防治作用。此外,半乳精胺所致肝衰竭模型同时也可用于肝肾综合征发病机理与防治的研究。The experiments were designed to study the relation between endotoxamia and renal insufficiency and the protective effects of RSM on galactosamine-induced acute hepatic failure. The results indicated that galactosamine-treated rats which all accompanied with endotoxamia exhibited significant renal dysfunction (Per, BUN elevated; UV, Ccr, U_(Na)V fell; FE_(H2O), FE_(Na) enhanced). After treatment of RSM, the endotoxemia was reduced while renal functions were improved. It suggested that there was a close relationship between endotoxemia and renal insufficiency. The experiment proved that the endotoxin was an important factor in the occurance and development of HRS. RSM possessed marked preventive and theraputic effects for HRS. In addition, the model of galactosamine-induced hepatic failure could be used to study the pathogenesis, prevention and therapy of HRS simultaneously.

关 键 词：肝病 肝衰竭 肾衰竭 内毒素 

分 类 号：R575.302[医药卫生—消化系统]