白血病细胞内磷酸单酯的^(31)P核磁共振分析  

Analysis of Phosphomonoesters in Leukemic Cell Lines by ^(31)P Nuclear Magnetic Resonance

作　　者：黄荣清[1] 舒融[1] 颜贤忠[2] 骆传环[1] 杜泽涵[2] 

机构地区：[1]军事医学科学院放射医学研究所,北京100850 [2]军事医学科学院国家生物医学分析中心,北京100850

出　　处：《分析测试学报》2002年第4期5-7,共3页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目 (29905005);北京市自然科学基金资助项目 (7002029)

摘　　要：对人早幼粒白血病细胞HL_60和人淋巴瘤白血病细胞Molt_4的 31PNMR谱进行了分析 ,HL_60和Molt_4细胞显示很强的磷酸单酯峰 ,磷酸单酯峰中包含有磷酸胆碱和磷酸乙醇胺 ;并进一步对磷酸单酯峰的特征及形成进行了分析 ;P nuclear magnetic resonance spectroscopy was used for the analysis phosphorus containing compounds in human lymphoma leukemia cell line Molt- 4 and human promyelocyte leukemia cell line HL- 60. As compared with nontumorous cells the two leukemic cells have a strong phosphomonoester peak. The character and formation of the peak were discussed. The phosphomonoester peak was composed of two peaks of phosphoethanolamine and phosphocholine. The results indicated possibility for clinical diagnosis and analysis of tumor based on the phosphomonoester peak.

关 键 词：白血病 细胞 核磁共振 磷酸单酯 诊断 

分 类 号：R733.7[医药卫生—肿瘤] R445.2[医药卫生—临床医学]