用α-苯乙胺拆分制备高光学活性线性二级醇  

Preparation of Linear Secondary Alcohols of High Optical Purity through Chemical Resolution with Chiral α-Phenylethylamines

作　　者：苏贤斌[1] 张奇涵[1] 武永庆[1] 许家喜[1] 

机构地区：[1]北京大学化学与分子工程学院,生物有机与分子工程教育部重点实验室,北京100871

出　　处：《有机化学》2002年第7期496-500,共5页Chinese Journal of Organic Chemistry

摘　　要：用手性α 苯乙胺作为拆分剂以较好的收率拆分了具有线性结构的二级醇 ,1 对烷基苯基取代的乙醇和α 苯丙醇 ,光学纯度达 92 %～ 98% .Linear secondary alcohols 1 para alkylphenylethanols and α phenylpropanol were resolved with commercially available chiral 1 phenylethylamines in good yields with high enantiomeric excess (92% to 98%). The influence of the structure of secondary alcohols on the resolution was also studied.

关 键 词：Α-苯乙胺 光学活性 线性二级醇 化学拆分 手性醇 乙醇 丙醇 

分 类 号：O623[理学—有机化学]