脑发育异常性癫痫脑组织的MDR-1、MRP和GFAP表达一例并文献复习  

The expression of MDR-1, MRP and GFAP in the resected brain tissue from a case of cortical dysplasia with intractable epilepsy

作　　者：丁成云[1] 栾国明[2] 徐群渊[1] 杨慧[1] 

机构地区：[1]首都医科大学北京神经科学研究所,北京100053 [2]北京市神经外科研究所

出　　处：《中华神经外科杂志》2002年第4期231-233,共3页Chinese Journal of Neurosurgery

摘　　要：目的　观察灰质异位性难治性癫痫中多药耐药基因蛋白 (MDR 1)、耐药基因相关蛋白 (MRP)及胶质纤维酸性蛋白 (GFAP)在发育异常性脑组织中的表达情况。方法　对确诊为脑灰质异位性症状性癫痫患者手术切除下病灶组织行免疫组化染色 ,观察脑组织中MDR 1、MRP及GFAP的表达情况。结果　在手术切除的病灶组织中 ,除一些增生性的星形胶质细胞同时具上述三种蛋白的阳性标记外 ,在一些异形的神经元内同时还存在有MDR 1和MRP的阳性表达。结论　灰质异位性难治性癫痫中MDR 1、MRP及GFAP不仅可在一些反应性的星形胶质细胞中表达 。Objective To observe the expression of MDR 1,MRP and GFAP in the resected brain tissues of corical dysplasia. Methods The brain tissue was resected in a clinical case who was diagnosed as cortical dysplasia with intractable epilepsy, The specimen was stained immunohistochemically to observe the expression of MDR 1, MRP and GFAP. Results An over expression of immunoreactivities for MDR 1 and MRP was found at both reactive astrocyte and some giant dysplastic neurons, while the overexpression of GFAP could only be found at some reactive astrocyte. Conclusions The overexpression of MDR 1 and MRP can be found at some giant dysplasia neurons in patients of cortical dysplasia with intractable epilepsy.

关 键 词：脑发育异常性癫痫 难治性癫痫 灰质异位 反应性星形胶质细胞 异形神经元 MDR-1 MRP GFAP 脑质纤维酸性蛋白 多药耐药基因蛋白 耐药基因相关蛋白 

分 类 号：R742.1[医药卫生—神经病学与精神病学]