大骨节病儿童尿液游离氨基酸谱短期动态变化  

study on changes of amino acid profile in urine in Kaschin—Beck disease chidren in short—term

作　　者：朱大岭[1] 杨燕[1] 

机构地区：[1]中国地方病防治研究中心大骨节病研究所

出　　处：《中国地方病学杂志》1991年第4期206-208,共3页Chinese Jouranl of Endemiology

摘　　要：本文报告了大骨节病儿童尿液游离氨基酸谱短期动态变化的情况。在病情活跃时,丝氨酸、天门冬氨酸、谷氨酸、苏氨酸、丙氨酸、脯氨酸、甲硫氨酸、色氨酸、异亮氨酸、苯丙氨酸和组氯酸尿中的含量病区儿童明显高于非病区儿童;随着病情好转,大部分氨基酸恢复到正常水平,仅丝氨酸、谷氨酸仍高于非病区。作者认为前者可能反映致大骨节病因子活跃的情况,与病理的破坏过程有关;丝氨酸、谷氨酸似乎同病理的修复过程有关,并进行了扼要计论。This paper reported the change of amino acid profile in urine in KBDchildren in short—term.When the disease was serious,the values of Ser,Asp,Glu,The,Ala,Pro,Mat,Trp,Lie,Phe,and His in children's urine ofendemic area were higher than those of non—endemic area.As the patients wererecovered by degrees most of the amino acids recovered to normal level,butSer,Glu were still increased.It is seemed that Ser,Glu refer to recoveryprocess of the disease,the rest reflect the activity of the factors causing thedisease and are thought to relate to pathologic recovery process of the disease.

关 键 词：大骨节病 尿液 游离氨基酸 儿童 

分 类 号：R726.841[医药卫生—儿科]