乳腺癌细胞基质MMP-9和TIMP-2的表达及其临床意义  

Expression of extracellular matrix MMP-9 and TIMP-2 in breast carcinoma and its signification

作　　者：孙慧[1] 战忠利[1] 李雯[1] 吴洁[1] 宁连胜[1] 

机构地区：[1]天津医科大学附属肿瘤医院,天津300060

出　　处：《临床与实验病理学杂志》2002年第3期268-270,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的 :研究乳腺癌组织中细胞外基质金属蛋白酶 9(MMP 9)和组织基质金属蛋白酶抑制剂 2 (TIMP 2 )的表达及其与淋巴转移和预后的相关性。方法 :通过免疫组织化学的方法检测 10 9例乳腺癌组织中MMP 9和TIMP 2表达的情况。结果 :MMP 9和TIMP 2在人乳腺癌中表达的阳性率分别为 6 6 97%和 30 2 7% ;MMP 9的表达与组织学分级、淋巴结转移呈正相关 (P <0 0 1) ,与术后生存率呈负相关 ,而TIMP 2的表达则相反。结论 :MMP 9和TIMP 2的表达与乳腺癌淋巴结转移与预后密切相关 。Purpose To investigate the expression of MMP-9 and TIMP-2 in breast carcinoma and its metastasis and prognosis. Methods One hundred and nine cases of breast carcinoma were studied by S-P immunohistological staining with MMP-9 and TIMP-2. Results The expression rate of MMP-9 were 66.97% and 30.27%. The expression of MMP-9 was positively correlated to histological grade and lymph node metastasis and negatively to survival time. The expression of TIMP-2 was negatively correlated to lymph node metastasis and positively to survival time. Conclusion The expression of MMP-9 and TIMP-2 are closely correlated to histological grade and lymph node metastasis and its survival time in breast carcinoma which may serve as parameter for determing tumor biological behavior and prognosis.

关 键 词：乳腺癌 细胞基质 MMP-9 TIMP-2 临床意义 乳腺肿瘤 免疫组织化学 金属蛋白酶类 

分 类 号：R737.9[医药卫生—肿瘤] R730.23[医药卫生—临床医学]