初发及复发转移大肠癌组织与外周血MDR-1基因表达相关性研究  

The relationship between the expression of MDR-1 in carcinoma tissue and in extroperiblood of primary and recurrent metastatic adenocarcinoma of colon and rectum

作　　者：白玉贤[1] 吴瑾[2] 崔滨滨[2] 郝克倩 

机构地区：[1]哈尔滨医科大学第三临床医学院内科,150040 [2]哈尔滨医科大学第三临床医学院腹外科,150040 [3]黑龙江省第五医院

出　　处：《肿瘤防治研究》2002年第4期264-266,共3页Cancer Research on Prevention and Treatment

基　　金：黑龙江省九五攻关项目 (G99C19 5 )

摘　　要：目的　探讨初发及复发转移大肠癌组织与外周血MDR 1基因表达的相关性。方法　采用RT PCR方法分别检测了 5 6例初发大肠癌组织及外周血和 4 0例术后化疗的复发转移大肠癌病灶组织及外周血的MDR 1表达情况。结果　无论是组织中 ,还是外周血中经过化疗的大肠癌患者MDR 1的阳性表达率均明显高于初发大肠癌患者 ,统计学上有显著性差异 (P <0 .0 5 )。结论　可以用外周血代替癌组织来检测MDRObjective To explore the relationship between the expression of MDR\|1 gene in carcinoma tissue and in extroperiblood of primary and recurrent metastatic adenocarcinoma of colon and rectum.Methods Detect the expression of MDR\|1 in carcinoma tissue and extroperiblood of 50 cases of primary and 40 cases of recurrent of metastatic adenocarcinoma of colon and rectum after surgical resection by RT\|PCR respectively.Results Whether in tissue or in extroperiblood, those treated by chemotherapy have significantly higher positive rate than those of primary ones ( P <0.05).Conclusion We can use the extroperiblood in place of the carcinoma tissue to detect the expression of MDR\|1 gene.

关 键 词：大肠癌 MDR-1基因 相关性 外周血 肿瘤化疗 复发 RT-PCR 

分 类 号：R735.34[医药卫生—肿瘤]