鳞状上皮细胞癌抗原在宫颈癌患者血清中的表达及其与临床病理特征的关系  

Serum squamous cell carcinoma antigen in patients with cervical carcinoma and its relationship with clinical pathological characteristics

作　　者：钟雷[1] 张继青[2] 

机构地区：[1]广州军区武汉总医院门诊部,湖北武汉430070 [2]广州军区武汉总医院肿瘤科,湖北武汉430070

出　　处：《实用医院临床杂志》2014年第4期83-84,共2页Practical Journal of Clinical Medicine

摘　　要：目的观察鳞状上皮细胞癌抗原(squamous cell carcinoma antigen,SCCAg)在宫颈癌患者血清中的表达,探讨其与临床病理特征的关系。方法采用酶联免疫吸附法检测84例宫颈癌患者(宫颈癌组)、38例宫颈上皮内瘤样病变(cervical intraepithelial neoplasia,CIN)患者(CIN组)和40例门诊健康体检妇女(对照组)血清SCCAg表达水平,分析其与临床分期、组织学类型、肿瘤组织大小、生长类型及组织分化程度等临床病理特征的关系。结果宫颈癌各临床分期患者血清SCCAg表达水平均明显高于CIN组和对照组(P<0.05),其表达与生长类型、组织分化程度无明显相关性(P>0.05),而与临床分期、组织学类型及肿瘤组织大小有明显的相关性(P<0.01或P<0.05),并有随临床分期逐渐进展而增加的趋势(P<0.05)。结论临床分期是影响宫颈癌患者血清SCCAg表达水平的重要因素,临床分期较高的患者应加强血清SCCAg表达水平的监测,以有效控制病情进展。Objective To detect the expression of squamous cell carcinoma antigen（SCCAg） in serum of cervical cancer patients,and to explore its relationship with clinical pathological characteristics.Methods The serum levels of SCCAg of 84 cases with cervical cancer（CC group）,38 cases with cervical intraepithelial neoplasia（CIN group） and 40 healthy women（control group） were assayed by an enzyme linked immunosorbent assay.The relationship between SCCAg levels and clinical pathological features such as clinical staging,histological type,tumor size,growth type and differentiation degree were analyzed.Results The serum levels of SCCAg in the CC group were significantly higher than that in the CIN control groups（P 〈0.05）.There was no significant correlation between SCCAg and tumor growth type or degree of differentiation.However,serum levels of SCCAg were significantly correlated with clinical stage,histological type and tumor size（P 〈 0.01 and P〈0.05）,and the correlation was gradually increased with progress of clinical stages（P 〈0.05）.Conclusion The clinical stage was an important factor to influence the serum levels of SCCAg in patients with cervical cancer.Accordingly,it should strengthen the monitoring of serum SCCAg levels in patients with higher clinical stage in order to effectively control the disease progression.

关 键 词：鳞状上皮细胞癌抗原 宫颈癌 宫颈上皮内瘤样病变 

分 类 号：R737.33[医药卫生—肿瘤] R730.3[医药卫生—临床医学]