胶质瘤患者血浆D-二聚体变化及临床意义  

Clinical significance of plasma D-dimer in glioma patients

作　　者：蓝美锐[1] 陈礼刚 

机构地区：[1]四川省自贡市第四人民医院神经外科,四川自贡643000 [2]泸州医学院附属医院神经外科,四川泸州646000

出　　处：《实用医院临床杂志》2014年第4期149-151,共3页Practical Journal of Clinical Medicine

摘　　要：目的探讨脑胶质瘤患者血浆中D-二聚体含量变化及临床意义。方法采取前瞻性队列研究,纳入59例脑胶质瘤患者,分为恶性胶质瘤组(III^IV级)和低恶性胶质瘤组(I^II级),对照组纳入20名门诊健康体检者。测定各组人群血浆D-二聚体含量,分析其含量与胶质瘤恶性程度、预后间相关性。结果恶性胶质瘤组D-二聚体含量较低恶性胶质瘤组及对照组升高,差异有统计学意义(P<0.05)。恶性胶质瘤D-二聚体含量升高组生存时间明显短于正常组,差异有统计学意义(P<0.05)。结论脑胶质瘤患者血浆D-二聚体水平可能与胶质瘤恶性程度、预后相关。Objective To investigate the changes of plasma D-dimer in patients with glioma and its clinical significance.Methods By using prospective cohort study,59 patients with glioma were divided into high malignant glioma group（WHO Ⅲ-Ⅳ） and low malignant glioma group（WHO Ⅰ-Ⅱ）.At the same time,20 healthy subjects were used as controls.Levels of plasma D-dimer were measured and relationships between the plasma D-dimer and malignant degree as well as prognosis of the disease were analyzed.Results The levels of plasma D-dimer were increased in the malignant glioma group（P 〈0.05）,but no significant changes were found in the low malignant glioma group and the healthy control group.The levels of plasma D-dimer was associated with prognosis of the patients with malignant glioma.Conclusion The level of plasma D-dimer may be associated with the malignancy degree and prognosis.

关 键 词：胶质瘤 D-二聚体 恶性度 预后 

分 类 号：R739.41[医药卫生—肿瘤]