循环微小RNAs与内皮功能障碍相关疾病  

Circulating microRNAs in Vascular Biology and Endothelial Dysfunction-Related Diseases

作　　者：刘蜜[1] 郭渝成[1] 刘秀华[1] 

机构地区：[1]解放军总医院病理生理研究室,北京100853

出　　处：《生理科学进展》2014年第3期167-171,共5页Progress in Physiological Sciences

基　　金：国家科技支撑计划项目(2013BA108800)资助课题

摘　　要：循环微小RNAs（circulating miRNAs）是一类稳定存在于循环血中的长度约为19～22 nt的内源性小分子单链RNA,通过与靶mRNA特异性结合负性调节基因表达。血管内皮细胞可以产生循环miRNAs以调节自身及其他细胞的功能,同时受其他来源循环miRNAs的调控。循环miRNAs表达改变具有疾病特异性,有望成为内皮功能障碍相关疾病早期预警、诊断和预后评估的新的生物标志物。本文综述循环miRNAs的生物学特性及其在血管生物学及内皮功能障碍相关疾病中的作用。Circulating microRNAs（miRNAs） are a class of evolutionary conserved non-coding RNAs of19-22 nucleotides in circulating blood,that function as negative regulators of gene expression through specific combination with target mRNAs.Vascular endothelial cells can produce circulating miRNAs to regulate the function of themselves and other cells,as well as be regulated by circulating miRNAs from other sources.Changes of circulating miRNAs expression are disease-specific,therefore,they are expected to be the promising biomarkers for early warning,diagnosing and evaluating prognosis of the endothelial dysfunction-related disease.In this review,we will discuss the biological characteristics of circulating miRNAs and its role in vascular biology and endothelial dysfunction-related diseases.

关 键 词：循环miRNAs 血管生物学 内皮功能障碍相关疾病 

分 类 号：R363[医药卫生—病理学]