经动脉向恶性实体肿瘤组织灌注碳酸氢钠提高化疗药物疗效的初步观察  

Investigation of increasing efficacy of aterial infusion of NaHCO3 to solid malignant tumors in interventional chemotherapy

作　　者：范平生[1] 王玉秀[1] 李继德[1] 白虎[1] 冯克海[1] 汪世存[2] 林新民[2] 刘汝华[1] 胡礼源[1] 

机构地区：[1]安徽省立医院分院,合肥230031 [2]安徽省立医院

出　　处：《中国临床药理学与治疗学》2000年第4期336-338,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的经动脉向实体恶性肿瘤组织灌注碳酸氢钠,观察对ADM、MMC、5_Fu介入治疗的增效作用。方法随机分组为单纯介入化疗组和经动脉灌注碳酸氢钠后再灌注化学药物两组。Seldinger技术穿刺经股动脉进入肿瘤动脉血管 ,对照组单纯灌注化疗药物 ;治疗组先灌注碳酸氢钠再分别灌注生理盐水30ml和化疗药物。结果加用碳酸氢钠组部分缓解率明显高于单纯化疗组。结论向恶性肿瘤组织灌注碳酸氢钠可提高ADM、MMC。Aim To observe the effect of interventional therapy of 5-fluorouracil(5-Fu), mitomycin C (MMC) and adriamycin (ADM) on solid malignant turmors in association with aterial infusion of NaHCO3.Methods Patients were randomly divided into two groups.With Seldinger technique,through the femoral atery to tumor atery.The patients in the control group were infused by anticarcinoma agents simply ,and patients in the treatment group were initially infused by NaHCO3,and then by NS 30 ml and anticarcinoma agents seperately. Results Partial remission (PR) in the group treated with NaHCO3 and anticarcinoma agents was significantly higher than in the group treated simply with anticarcinoma agents.Conclusion Aterial infusion of NaHCO3 into malignant tumors can increase the efficacy of ADM,MMC and 5-Fu.

关 键 词：实体肿瘤 灌注 碳酸氢钠 化疗药物 疗效 

分 类 号：R730.53[医药卫生—肿瘤]