脑心综合征应用依达拉奉治疗前后心肌酶、BNP水平变化及意义  

Brain Heart Syndrome before and after the Treatment of Comprehensive Application of Edaravone,Myocardial Enzyme Levels and Significance of BNP

作　　者：尉飞[1] 

机构地区：[1]河南中医学院第一附属医院,河南郑州450003

出　　处：《中国医学创新》2014年第19期31-34,共4页Medical Innovation of China

摘　　要：目的:分析脑心综合征应用依达拉奉治疗前后心肌酶、BNP水平变化及意义。方法:选取2011年5月-2013年10月在本院进行治疗的脑心综合征患者80例为研究对象进行分析,按随机数字表法分为对照组和研究组,两组给予相同常规治疗,研究组在此基础上应用依达拉奉注射液治疗,对比两组患者治疗2周后临床总有效率、心肌酶(以血清AST、LDH、CK、CK-MB为主)和BNP变化。结果:研究组治疗总有效率82.5%,显著高于对照组57.5%,比较差异具有统计学意义(P<0.05);研究组患者心肌酶指标(AST、LDH、CK、CK-MB)、BNP水平显著低于对照组,心肌损害和心力衰竭等情况比对照组稍轻,比较差异具有统计学意义(P<0.05)。结论:应用依达拉奉治疗脑心综合征患者心肌酶与BNP水平显著降低,可改善心肌损害与心力衰竭等症状,改善预后,有较高应用价值。Objective： To analyze brain heart syndrome before and after the treatment of comprehensive application of edaravone, myocardial enzyme levels and significance of BNP.Method： From 2011 May to 2013 October in our hospital for treatment of brain heart syndrome 80 patients were selected as the research object to analyze, who were randomly divided into control group and study group. The two groups were given the same routine treatment, and the study group based on the application of Edaravone injection treatment. The clinical total effective rate, myocardial enzymes （LDH, CK, serum AST, CK-MB and BNP change） between the two groups after two weeks of treatment were compared. Result： The treatment group total effective rate 82.5% was significantly higher than that of the control group 57.5%, with statistically significant differences （P〈0.05）. Patients with myocardial enzyme indexes （AST, LDH, CK, CK-MB）, BNP levels were significantly lower than those of the control group, mean myocardial injury and heart failure were slightly lighter than those of the control group, with statistically significant differences （P〈0.05）.Conclusion： Application of edaravone in the treatment of cerebral cardiac syndrome in patients with myocardial enzyme and BNP level decreased significantly, can improve symptoms of heart failure, myocardial damage and improve prognosis, has higher application value.

关 键 词：脑心综合征 依达拉奉 心肌酶 BNP 心肌损害 

分 类 号：R743.3[医药卫生—神经病学与精神病学]