防治老年大肠癌患者奥沙利铂周围神经毒性致感觉异常的临床观察  

Clinical observation of prevention from peripheral nerve toxicity in elderly patients caused by oxaliplatin

作　　者：汤雪峰[1] 李财宝[1] 黄建平[1] 

机构地区：[1]上海中医药大学附属曙光医院普外科,上海市200021

出　　处：《老年医学与保健》2014年第3期197-199,共3页Geriatrics & Health Care

摘　　要：目的 研究外用活血通络方对减弱老年大肠癌患者奥沙利铂诱发神经毒性的疗效观察.方法 将65例使用含奥沙利铂化疗方案的老年大肠癌患者,随机分为对照组和治疗组,分别用安慰剂（40℃温水）和活血通络方（40℃）浸泡四肢末端比较两组的疗效.结果 治疗组33例中未发生神经毒性有26例（78.8％）,发生Ⅰ级神经毒性有5例（15.2％）,发生Ⅱ级神经毒性有2例（6.1％）,无Ⅲ、Ⅳ级神经毒性发生.对照组32例中未发生神经毒性有14例（43.8％）,发生Ⅰ级神经毒性有8例（25％）,发生Ⅱ级神经毒性有6例（18.8％）,发生Ⅲ级神经毒性有3例（9.4％）,发生Ⅳ级神经毒性有1例（3.1％）.经非参数检验,Mann-WhitneyU统计量为3.106,P=0.01.提示两组间不同神经毒性分级的构成比不同,差异有统计学意义.结论 活血通络方外用能有效减弱老年大肠癌患者奥沙利铂所致的神经毒性.Objective To study the efficacy of Huo Xue Tong Luo decoction in elderly patients with colorectal cancer. Methods 65 patients with oxaliplatin-containing chemotherapy were randomly divided into the control group and the treatment grouprespectively. The control group received placebo （40℃ warm water） while treatment group received Huo Xue Tong Luo Fang （40℃） Soak extremities, and symptom and efficacy between two groups were compared. Results 26 cases in the treatment group didn＇t occur neurotoxicity （78.8%）, 5 cases I grade neurotoxicity （15.2%）, 2 cases Ⅱ neurotoxicity （6.1%）, no Ⅲ, Ⅳneurotoxicity occurred. 14 cases in the control group didn＇t occur neurotoxicity （43.8%）, 8 cases Ⅰ grade neurotoxicity （25%）, 6 cases Ⅱ neurotoxicity （18.8%）, 3 cases Ⅲ neurotoxicity （9.4%）, 1 case Ⅳ neurotoxicity. （3.1%）. By the Nonparametric test, Mann-Whitney U was 3.106, P=0.01, the date was statistical significance. Conclusion Huo Xue Tong Luo Fang was effective in attenuation of oxaliplatininduced neurotoxicity.

关 键 词：奥沙利铂 神经毒性 活血通络方 老年大肠癌患者 

分 类 号：R735[医药卫生—肿瘤]