放疗同步多西他赛加顺铂对非小细胞肺癌临床研究  

Clinical study of radiotherapy combination docetaxel and cisplatin in stage Ⅲ non-small cell lung cancer

作　　者：王青民[1] 杨敬磊[1] 郝秀仙[1] 

机构地区：[1]青岛市肿瘤医院放射治疗科,山东省266042

出　　处：《中华临床医师杂志（电子版）》2014年第11期31-34,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨放射治疗与多西他赛加顺铂同步对非小细胞肺癌(NSCLC)的治疗效果与不良反应。方法自2008年11月至2010年11月对60例Ⅲ期NSCLC患者随机分成两组,一组行单纯放疗,另一组采用放疗同步合并多西他赛加顺铂。治疗结束后,根据患者放疗后CT检查评价,比较两组疗效;并按WHO制定的药物毒性标准比较两组的不良反应。结果单纯放疗组(单放组)治疗后总有效率为36.6%,而同步治疗组(同步组)则为70.0%(P<0.05)。ⅢA期单放组1、2年生存率分别为61.5%、38.4%;同步组为73.3%、46.6%;ⅢB期单放组1、2年生存率分别为52.9%、20.0%;同步组为66.6%、33.3%(P>0.05);单放组仅1例患者生存3年以上,而同步组3年生存率为26.6%,显著高于单放组3.3%(P<0.01)。不良反应两组无统计学意义。结论放射治疗同步多西他赛加顺铂对局部晚期NSCLC的治疗价值具有协同作用,且不增加不良反应,显示出较好的临床疗效,并能显著提高不能手术的ⅢA、ⅢB期NSCLC患者的生存率。Objective To explore the efficacy and side effect of radiotherapy combined with docetaxel and cisplatin in the treatment of non-small cell lung cancer. Methods From November 2008 to November 2010, 60 cases in stage Ⅲ non-small cell lung cancer were randomly allocated into two groups. One group received radiotherapy, the other group received radiotherapy combined with docetaxel and cisplatin. After the treatment, studying the efficacy and side effect between the two groups. Results The response rate was 36.6% in single radiotherapy group and 70% in the concurrent radio-chemotherapy group. There was significant difference between the two groups（P〈0.05）. ⅢA 1, 2 year survival rate was 61.5%, 38.4% in single-radiotherapy group and 73.3%, 46.6% in the concurrent radio-chemotherapy group. ⅢB 1, 2-year survival rate was 52.9%, 20% and 66.6%, 33.3%. There was no significant difference between the two groups（P〉0.05）. The 3-year survival rate was 3.3% in single-radiotherapy group and 26.6% in the concurrent radio-chemotherapy group. There was significant difference between the two groups（P〈0.05）. The side effect between the two groups was not significantly. Conclusion Concurrent radiochemotherapy, compared with radiotherapy, could obviously enhance the long-term survival rate of patients in the unresectable state ⅢA/ⅢB non-small cell lung cancer, and dose not increase the serious toxicities.

关 键 词：癌 非小细胞肺 放射疗法 药物疗法 

分 类 号：R734.2[医药卫生—肿瘤]