Pokemon蛋白在膀胱尿路上皮癌中的表达及其意义  

Expression of Pokemon protein and its clinical significance in bladder transitional cell carcinoma

作　　者：侯列军[1] 虞亦鸣[1] 孙灵军[1] 虞建达[1] 

机构地区：[1]宁波大学医学院附属医院泌尿外科,浙江宁波315020

出　　处：《中国医药导报》2014年第19期56-58,共3页China Medical Herald

基　　金：宁波大学科研项目(编号xyy12018)

摘　　要：目的检测膀胱尿路上皮癌组织中Pokemon蛋白的表达,分析其与临床病理特征间的关系。方法收集2010年3月～2013年8月宁波大学附属医院泌尿外科27例膀胱尿路上皮癌术中切除的癌、癌旁及临近正常组织,应用免疫印迹法（Western blot）检测标本中Pokemon蛋白的表达,并对其与膀胱癌的临床病理特征进行分析。结果 Western blot检测到Pokemon蛋白在膀胱尿路上皮癌组织中表达较高、在癌旁及正常组织中表达较低,差异有统计学意义（P〈0.05）。膀胱癌组织中Pokemon蛋白表达与肿瘤病理分级有关,而与患者的性别、年龄、吸烟史及TNM临床分期无明显相关。结论 Pokemon蛋白表达和膀胱尿路上皮癌的发病及恶性程度有关,可能成为膀胱尿路上皮癌治疗的有效靶点。Objective To explore the expression of Pokemon protein in bladder transitional cell carcinoma and its correlation with clinical features. Methods From March 2010 to August 2013, at Department of Urinary Surgery in Affiliated Hospital of Ningbo University, 27 resection samples of patiens with bladder transitional cell carcinoma, including carcinoma tissue, paracancerous tissue and normal tissue were selected. Western blot was applied to detect the expression of Pokemon protein in tissue and clinical-pathological features was analyzed. Results The result of Westen blot showed that the expression of Pokemon protein in bladder transitional cell carcinoma tissue was significantly higher than those of paracancerous tissue and normal tissue, the differences were statistically significant（P〈0.05）. The expression of Pokemon was related to different tumor degree, and no related to patient＇s gender, age, smoking history and TNM stages. Conclusion Pokemon protein is expressed in bladder transitional cell carcinoma and it may play a key role in the genesis of transitional cell carcinoma of bladder. It may be the therapeutic target of transitional cell carcinoma of bladder in the future.

关 键 词：Pokemon蛋白 膀胱尿路上皮癌 免疫印迹 

分 类 号：R737.11[医药卫生—肿瘤]