Microarray-based analyses of monocytes from Chinese Uygur patients with Parkinson＇s disease and cognitive impairment  

作　　者：Luo Qin Xia Huan Yang Xinling 

机构地区：[1]Department of Neurology Center,First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054,China [2]Cadre Wards,Cancer Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830000,China

出　　处：《Chinese Medical Journal》2014年第12期2386-2388,共3页中华医学杂志（英文版）

基　　金：This study was supported by grants from the National Natural Science Foundation of China （No.81160143） and Xinjiang Uygur Autonomous Region Science and Technology Supporting Project in Xinjiang（No.201191162）.

摘　　要：Parkinson＇s disease （PD）, a complex neurodegenerative disease, is characterized by the loss of dopamine neurons in the substantia nigra ot the midbraln. PD patients have varying degrees of cognitive impairment （CI） that we term PD-CI. However, the etiology of these changes remains unexplained. We chose three Uygur male patients with PD-CI and three healthy controls of the same of nationality and sex to explore the pathogenesis of Xinjiang Uygur PD-CI using microarray-based gene expression profiling of monocytes.Parkinson＇s disease （PD）, a complex neurodegenerative disease, is characterized by the loss of dopamine neurons in the substantia nigra ot the midbraln. PD patients have varying degrees of cognitive impairment （CI） that we term PD-CI. However, the etiology of these changes remains unexplained. We chose three Uygur male patients with PD-CI and three healthy controls of the same of nationality and sex to explore the pathogenesis of Xinjiang Uygur PD-CI using microarray-based gene expression profiling of monocytes.

关 键 词：MICROARRAY UYGUR Parkinson＇s disease cognitive impairment 

分 类 号：R742.5[医药卫生—神经病学与精神病学]