白介素-22在炎症性肠病中的作用  

Role of IL-22 in inflammatory bowel disease

作　　者：孟娅[1] 王烜[1] 

机构地区：[1]泸州医学院附属医院消化内科,四川省泸州市646000

出　　处：《世界华人消化杂志》2014年第16期2258-2264,共7页World Chinese Journal of Digestology

摘　　要：白介素-22(interleukin-22,IL-22),是一个新型的IL-10相关因子,最初发现于2000年,以后人们不断探索发现IL-22参与多种炎症性疾病以及自身免疫性疾病的发病过程.尽管IL-22及其受体在基因水平与炎症性肠病(inflammatory bowel disease,IBD)无明确关联,仍有很多研究表明IL-22在IBD患者肠黏膜表达增强.从几个IBD临床前模型的数据表明,IL-22通过加强肠道上皮屏障的完整性和先天免疫而发挥一定的保护作用.IBD易感基因如IL-23R、IL-17和信号传导与转录激活因子3(signal transducer and activator of transcription3,STAT3)的功能,直接或间接地与IL-22相关,因此,对IL-22的进一步研究不仅能进一步了解IBD的基本机制,还能为把IL-22作为该病一个新的治疗措施提供理论依据.Interleukin-22（IL-22）, a novel IL-10 associated factor, was originally discovered in 2000. It has been found that IL-22 is involved in the pathogenesis of a variety of inflammatory and autoimmune diseases. Although IL-22 and its receptor have not been linked with inflammatory bowel disease（IBD） genetically, expression of IL-22 is augmented in patients with IBD. Despite the fact that IL-22 is correlated with disease activities in IBD patients, data from several preclinical models suggest that IL-22 exerts protective functions.IBD susceptibility genes such as IL-23R, IL-17 and signal transducer and activator of transcription3（STAT3） are functionally associated with IL-22directly or indirectly. These findings suggest that further studies on IL-22 would have the potential not only to analyze the fundamental mechanism of IBD but also to provide important rationale to develop novel therapeutic measures for this disorder.

关 键 词：白介素-22 克罗恩病 溃疡性结肠炎 

分 类 号：R574.62[医药卫生—消化系统]